trifluoroacetic acid in dichloromethane 3 h; Ambient temperature;

Stage #1: <a href="#" onclick="return RXDsubstances(event, this, '4876458', constants.ctx, '0')">N-Boc-6,7 dimethoxytetrahydroisoquinoline</a> <b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1209227', constants.ctx, '0')">n-butyllithium</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '1730733', constants.ctx, '0')">hexane</a> <br />T=-50&deg;C;&nbsp;0.0666667&nbsp;h;&nbsp;&nbsp;Inert atmosphere;&nbsp;<br />Stage #2: <a href="#" onclick="return RXDsubstances(event, this, '973727', constants.ctx, '0')">1,2-dimethoxy-4-chloromethyl-benzene</a> &nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '1730733', constants.ctx, '0')">hexane</a> <br />T=-50 - 20&deg;C;&nbsp;16&nbsp;h;&nbsp;&nbsp;Inert atmosphere;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 74 percent / (C₂H₅)3N / CH₂Cl₂ / 18 h / Ambient temperature<br />2: 1) N,N,N',N'-tetramethylethylenediamine, t-BuLi / THF, pentane 1) -78 deg C, 40 min 2) -78 deg C, 3 h<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 74 percent / (C₂H₅)3N / CH₂Cl₂ / 18 h / Ambient temperature<br />2: 1) N,N,N',N'-tetramethylethylenediamine, t-BuLi / THF, pentane 1) -78 deg C, 40 min 2) -78 deg C, 3 h<br /> <br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1732991', constants.ctx, '0')">N,N,N',N,-tetramethylethylenediamine</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '3587204', constants.ctx, '0')">tert.-butyl lithium</a> <br />&nbsp;THF, pentane 1) -78 deg C, 40 min 2) -78 deg C, 3 h;&nbsp;&nbsp;Yield given. Multistep reaction;&nbsp;<br /> &nbsp;