1-(3,4-二氢-2(1H)-异喹啉基)乙酮合成路线 (共 29 条)
反应条件
1: aqueous nitric acid; sulfuric acid 2: hydrogen chloride; ethanol View Scheme
参考文献
Ochiai; Nakagome
Chemical and Pharmaceutical Bulletin, 1958 , vol. 6, p. 497,500
反应条件
NH4Br; ethylenediamine T=70°C; 5 h; Microwave irradiationInert atmosphereneat (no solvent);
参考文献
Shimizu, Yuhei; Morimoto, Hiroyuki; Zhang, Ming; Ohshima, Takashi
Angewandte Chemie - International Edition, 2012 , vol. 51, # 34 p. 8564 - 8567
反应条件
1: aqueous nitric acid; sulfuric acid 2: hydrogen chloride; ethanol 3: mercury (II)-acetate; aqueous acetic acid / 150 °C View Scheme
参考文献
Ochiai; Nakagome
Chemical and Pharmaceutical Bulletin, 1958 , vol. 6, p. 497,500
反应条件
1.1: AlCl3, aluminium chloride 2.1: sodium hydroxide / water 2.2: 20 °C View Scheme
参考文献
Krysko, Andrei A.; Samoylenko, Georgiy V.; Polishchuk, Pavel G.; Fonari, Marina S.; Kravtsov, Victor Ch.; Andronati, Sergei A.; Kabanova, Tatyana A.; Lipkowski, Janusz; Khristova, Tetiana M.; Kuz'Min, Victor E.; Kabanov, Vladimir M.; Krysko, Olga L.; Varnek, Alexandre A.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 15 p. 4646 - 4661
反应条件
1: aqueous nitric acid; sulfuric acid
2: palladium/charcoal; ethanol / Hydrogenation
View Scheme
参考文献
Ochiai; Nakagome
Chemical and Pharmaceutical Bulletin, 1958 , vol. 6, p. 497,500
反应条件
tert.-butylhydroperoxide; Cu(NO3)2*3H2O in decane
T=0 - 50°C;
参考文献
Ghobrial, Michael; Schnuerch, Michael; Mihovilovic, Marko D.
Journal of Organic Chemistry, 2011 , vol. 76, # 21 p. 8781 - 8793
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=20°C; Reduction; 4 h;
参考文献
Sugiura, Michiharu; Asai, Koosuke; Hatano, Keiichiro; Kurono, Yukihisa; Hamada, Yoshiki
Heterocycles, 2000 , vol. 53, # 4 p. 821 - 830
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=20 - 60°C; 0.116667 h; Product distribution / selectivity;
参考文献
HAMMERSMITH IMANET LIMITED
Patent: WO2008/75043 A1, 2008 ;
Location in patent: Page/Page column 15-16 ;
反应条件
chlorosulfonic acid in dichloromethane
参考文献
SmithKline Corporation
Patent: US4228170 A1, 1980 ;