(S)-1-Boc-吡咯烷-3-甲酸合成路线 （共 16 条）
反应条件
sodium hydroxide in methanol; water T=20°C; 2 h;
参考文献
Murphy, John A.; Tripoli, Regis; Khan, Tanweer A.; Mali, Umesh W.
Organic Letters, 2005 , vol. 7, # 15 p. 3287 - 3289
反应条件
triethylamine; palladium on charcoal in acetic acid
反应条件
1: 92 percent / H2 / 10 wt percent Pd/C / ethyl acetate 2: 85 percent / 2N NaOH / methanol / 20 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 4 p. 673 - 682
反应条件
1: 70 percent / 9-borabicyclo[3.3.1]nonane (BBN) / tetrahydrofuran / Heating 2: 92 percent / H2 / 10 wt percent Pd/C / ethyl acetate 3: 85 percent / 2N NaOH / methanol / 20 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 4 p. 673 - 682
反应条件
1: 99 percent / methanol / Heating 2: 70 percent / 9-borabicyclo[3.3.1]nonane (BBN) / tetrahydrofuran / Heating 3: 92 percent / H2 / 10 wt percent Pd/C / ethyl acetate 4: 85 percent / 2N NaOH / methanol / 20 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 4 p. 673 - 682
反应条件
1: 73 percent / CH2Cl2 / 16 h / 20 °C 2: aq. NaOH / methanol / 0.25 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 7 p. 2052 - 2059
反应条件
1: 73 percent / CH2Cl2 / 16 h / 20 °C 2: aq. NaOH / methanol / 0.25 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 7 p. 2052 - 2059
反应条件
1: C57H59O5P2Rh; hydrogen / toluene / 60 h / 45 °C / 22502.3 Torr 2: Cornforth reagent / N,N-dimethyl-formamide; toluene / 20 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 134, # 15 p. 6607 - 6616
反应条件
thionyl chloride T=20°C; Reflux;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2009/5998 A1, 2009 ;
Location in patent: Page/Page column 252-253 ;
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C 2: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C View Scheme
参考文献
INTERMUNE, INC.; BUCKMAN, Brad, O.; NICHOLAS, John, B.; EMAYAN, Kumaraswamy; SEIWERT, Scott, D.
Patent: WO2013/25733 A1, 2013 ;
