2-甲酰基-3-氯苯并噻吩合成路线 （共 10 条）
反应条件
tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide in dichloromethane 0.166667 h; Molecular sieve 4A;
参考文献
ALLERGAN, INC.
Patent: US2006/106088 A1, 2006 ;
Location in patent: Page/Page column 15; sheet 1 ;
US 20060106088 A1
反应条件
N,N-dimethyl-formamide; trichlorophosphate T=20 - 80°C; 3.5 h; Heating / reflux;
参考文献
AFFINIUM PHARMACEUTICALS, INC.
Patent: WO2004/52890 A1, 2004 ;
Location in patent: Page 47; 79 ;
WO 2004/052890 A1
反应条件
1: With trichlorophosphate T=80°C; 2 h; 2: With water; sodium acetate Cooling with ice;
参考文献
Paul, Nidhin; Muthusubramanian, Shanmugam
Tetrahedron Letters, 2011 , vol. 52, # 29 p. 3743 - 3746
反应条件
trichlorophosphate T=0 - 80°C; 2 h;
参考文献
Paul, Nidhin; Muthusubramanian, Shanmugam
Tetrahedron Letters, 2011 , vol. 52, # 29 p. 3743 - 3746
反应条件
water; trichlorophosphate 1), cooling 2) DMF, room temperature, 30 min; reflux, 4-6 h, 3) DMF; Yield given. Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 61, # 19 p. 6523 - 6525
反应条件
1: hydrogenchloride; LiAlH4 / tetrahydrofuran; methanol 2: TPAP; NMO / silica gel / dichloromethane View Scheme
反应条件
trichlorophosphate T=0 - 80°C; 2 h;
参考文献
Paul, Nidhin; Muthusubramanian, Shanmugam
Tetrahedron Letters, 2011 , vol. 52, # 29 p. 3743 - 3746
参考文献
Journal of Organic Chemistry, , vol. 23, p. 560,563
反应条件
SCl2 1.) CH2Cl2, r. t., 1 h, molar ratio of SCl2 to the starting material = 2; 2.) toluene, reflux, 5 h; Yield given. Multistep reaction;
参考文献
Phosphorus and Sulfur and the Related Elements, , vol. 16, p. 119 - 134
反应条件
sodium tetrahydroborate; ethanol T=0 - 20°C; 2 h;
参考文献
CHLORION PHARMA, INC.; UNIVERSITE LAVAL; ATTARDO, Giorgio; TRIPATHY, Sasmita
Patent: WO2010/132999 A1, 2010 ;
Location in patent: Page/Page column 83 ;
