N-(2-噻吩基甲基)吡啶-2-胺合成路线 (共 9 条)
反应条件
[RuCl(N,N-dimethyl-1-[6-(4'-methylphenyl)pyridin-2-yl]methaneamine(-H))(dppb)]; potassium tert-butylate in tetrahydrofuran; toluene T=110°C; 24 h; Inert atmosphereMolecular sieve;
参考文献
Agrawal, Santosh; Lenormand, Maud; Martin-Matute, Belen
Organic Letters, 2012 , vol. 14, # 6 p. 1456 - 1459
反应条件
copper(l) iodide; 1-(5,6,7,8-tetrahydroquinolin-8-yl)-ethanone; caesium carbonate in N,N-dimethyl-formamide T=25°C; Ullmann condensation; 14 h; Inert atmosphere;
参考文献
Wang, Deping; Ding, Ke
Chemical Communications, 2009 , # 14 p. 1891 - 1893
反应条件
sodium amide; toluene
参考文献
Abbott Labor
Patent: US2713048 , 1950 ;
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Abbott Labor
Patent: US2566556 , 1946 ;
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Kyrides et al.
Journal of the American Chemical Society, 1950 , vol. 72, p. 745,746
参考文献
Leonard; Solmssen
Journal of the American Chemical Society, 1948 , vol. 70, p. 2064,2066
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Abbott Labor
Patent: US2713048 , 1950 ;
参考文献
Kaye; Kogon
Recueil des Travaux Chimiques des Pays-Bas, 1952 , vol. 71, p. 309,314
反应条件
1: cumene 2: aqueous formic acid; cumene View Scheme
参考文献
Abbott Labor.
Patent: US2713048 , 1950 ;
反应条件
1: cumene 2: aqueous formic acid; cumene View Scheme
参考文献
Abbott Labor.
Patent: US2713048 , 1950 ;
反应条件
sodium hydroxide; benzene
参考文献
Abbott Labor.
Patent: US2556566 , 1946 ;
反应条件
1: 77 percent / NaNH2 / xylene / 96 h / Heating
2: 100 percent / hydroquinone, 2 N aq. HCl / 1 h / 80 °C
3: 5.4percent methanolic methylamine, 2 N methanolic HCl (to pH 7), NaCNBH3 / 24 h / Ambient temperature
View Scheme
参考文献
Ziegler; Ho; Castagnoli Jr.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 10 p. 1133 - 1138