1-叠氮-1-脱氧-β-D-吡喃半乳糖苷四乙酸酯合成路线 （共 22 条）
反应条件
1: HBr / acetic acid 2: TMS-N3; TBAF / tetrahydrofuran View Scheme
参考文献
Journal of the Chemical Society. Perkin Transactions 1, , # 8 p. 1042 - 1049
参考文献
Journal of the American Chemical Society, , vol. 128, # 50 p. 16030 - 16031
反应条件
sodium azide; tetra(n-butyl)ammonium hydrogensulfate; sodium hydrogencarbonate in dichloromethane
参考文献
Bioorganic and Medicinal Chemistry, , vol. 14, # 14 p. 4775 - 4780
反应条件
1: pyridine 2: HBr / acetic acid 3: TMS-N3; TBAF / tetrahydrofuran View Scheme
参考文献
Journal of the Chemical Society. Perkin Transactions 1, , # 8 p. 1042 - 1049
反应条件
2: sodium azide View Scheme
参考文献
Carbohydrate Research, , vol. 369, p. 58 - 62
反应条件
dibenzo-18-crown-6; sodium azide 1.) DMF, reflux, 20 min, 2.) pyridine, 3 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), , vol. 30, # 7 p. 1329 - 1331
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, , # 7 p. 1638 - 1641
反应条件
sodium methylate in methanol Inert atmosphere;
参考文献
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, , vol. 64, # 11-12 p. 1639 - 1652
反应条件
1: NaOMe / methanol / 0.5 h 2: H2 / Pd/C / methanol View Scheme
参考文献
Tamura, Masahiro; Nishizaki, Hiroshi; Miyazaki, Chiemi; Okai, Hideo
Bulletin of the Chemical Society of Japan, 1984 , vol. 57, # 11 p. 3167 - 3172
反应条件
1: 97 percent / H2 / PtO2 / ethyl acetate / 1 h 2: 1-hydroxybenzotriazol, 2-mercaptoethanol, dicyclohexylcarbodiimid / tetrahydrofuran / 1) -20 deg C, 1 h, 2) RT, 24 h 3: trifluoroacetic acid / CH2Cl2 / 1 h / Ambient temperature 4: NH3, trifluoroacetic acid / methanol; CH2Cl2 / 3 h / Ambient temperature; pH 10-11 View Scheme
参考文献
Vansteenkiste, Stefan; Schacht, Etienne; Haro, Isabel; Reig, Francesca; Parente, Antonio; Garcia-Anton, Jose Maria
Bulletin des Societes Chimiques Belges, 1991 , vol. 100, # 10 p. 759 - 766
反应条件
1: 97 percent / H2 / PtO2 / ethyl acetate / 1 h
2: 1-hydroxybenzotriazol, 2-mercaptoethanol, dicyclohexylcarbodiimid / tetrahydrofuran / 1) -20 deg C, 1 h, 2) RT, 24 h
3: trifluoroacetic acid / CH2Cl2 / 1 h / Ambient temperature
4: NH3, trifluoroacetic acid / methanol; CH2Cl2 / 3 h / Ambient temperature; pH 10-11
View Scheme
参考文献
Vansteenkiste, Stefan; Schacht, Etienne; Haro, Isabel; Reig, Francesca; Parente, Antonio; Garcia-Anton, Jose Maria
Bulletin des Societes Chimiques Belges, 1991 , vol. 100, # 10 p. 759 - 766
