2,4-二溴噻唑-5-甲醛合成路线 （共 7 条）
反应条件
phosphorus oxytribromide T=105°C; 6 h;
参考文献
Pereira, Raquel; Gaudon, Claudine; Iglesias, Beatriz; Germain, Pierre; Gronemeyer, Hinrich; De Lera, Angel R.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 1 p. 49 - 54
反应条件
1: 2,4-dibromo-1,3-thiazole With lithium diisopropyl amide in tetrahydrofuran T=-78°C; 0.666667 h; Inert atmosphere; 2: N,N-dimethyl-formamide in tetrahydrofuran T=-78°C; 1 h;
参考文献
PHENEX PHARMACEUTICALS AG; GEGE, Christian; STEENECK, Christoph; KINZEL, Olaf; KLEYMANN, Gerald; HOFFMANN, Thomas
Patent: WO2013/178362 A1, 2013 ;
Location in patent: Page/Page column 156 ;
反应条件
phosphorus oxytribromide in N,N-dimethyl-formamide T=20 - 108°C; 8 h;
参考文献
US2006/166906 A1, ;
Page/Page column 26 ;
反应条件
in (2S)-N-methyl-1-phenylpropan-2-amine hydrate
反应条件
hydrogen; sodium acetate; palladium on activated charcoal in methanol T=23°C; 12 h;
参考文献
Kerdesky; Seif
Synthetic Communications, 1995 , vol. 25, # 24 p. 4081 - 4086
反应条件
sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene in water; tert-butyl alcohol T=25°C; 0.25 h;
参考文献
Pereira, Raquel; Furst, Audrey; Iglesias, Beatriz; Germain, Pierre; Gronemeyer, Hinrich; De Lera, Angel R.
Organic and Biomolecular Chemistry, 2006 , vol. 4, # 24 p. 4514 - 4525
反应条件
sodium tetrahydroborate in methanol T=23°C; 2 h;
参考文献
Synthetic Communications, , vol. 25, # 17 p. 2639 - 2645
