1: potassium hydroxide; copper(l) iodide; 8-hydroxy-quinoline / dimethyl sulfoxide / 30 h / 100 °C / |Inert atmosphere; |Large scale 2: thionyl chloride / 3 h / 50 °C 3: N,N-dimethyl-formamide / |Heating 4: sodium hydroxide / methanol / 3 h / 50 °C View Scheme

1: potassium hydroxide; copper(l) iodide; 8-hydroxy-quinoline / dimethyl sulfoxide / 30 h / 100 °C / |Inert atmosphere; |Large scale 2: thionyl chloride / 3 h / 50 °C 3: N,N-dimethyl-formamide / |Heating 4: sodium hydroxide / methanol / 3 h / 50 °C 5: |Large scale View Scheme

copper(l) iodide; 8-hydroxy-quinoline; potassium hydroxide in dimethyl sulfoxide T=100°C; 30 h; Inert atmosphereLarge scale; Reagent/catalystTemperature;