N-(5,5,8,8-四甲基-5,6,7,8-四氢-2-萘)乙酰胺 (他米巴罗汀)合成路线 (共 2 条)
反应条件
aluminium trichloride in dichloromethane T=0°C; 0.333333 h;
参考文献
Eyrolles, Laurence; Kagechika, Hiroyuki; Kawachi, Emiko; Fukasawa, Hiroshi; Iijima, Tohru; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 10 p. 1508 - 1517
反应条件
hydrogenchloride; phosphorus pentachloride; sodium hydrogencarbonate; 2,3-dimethyl aniline in methanol; dichloromethane; water
参考文献
Shionogi and Co., Ltd.
Patent: US5214202 A1, 1993 ;