N-(2-氯乙基)-N'-3-吡啶基-脲合成路线 （共 4 条）
反应条件
in toluene T=0 - 20°C; 5.5 h;
参考文献
NOVARTIS AG; BOCK, Mark G.; GAUL, Christoph; GUMMADI, Venkateshwar Rao; SENGUPTA, Saumitra
Patent: WO2010/149755 A1, 2010 ;
Location in patent: Page/Page column 37-38 ;
WO 2010/149755 A1
反应条件
sodium nitrite in formic acid
T=0 - 5°C; 0.5 h;
参考文献
Crider; Lamey; Floss; Cassady; Bradner
Journal of medicinal chemistry, 1980 , vol. 23, # 8 p. 848 - 851
反应条件
sodium hydride in tetrahydrofuran; N,N-dimethyl-formamide
T=0 - 20°C;
参考文献
NOVARTIS AG; BOCK, Mark G.; GAUL, Christoph; GUMMADI, Venkateshwar Rao; SENGUPTA, Saumitra
Patent: WO2010/149755 A1, 2010 ;
Location in patent: Page/Page column 38 ;
WO 2010/149755 A1
反应条件
acetic acid in N-methyl-acetamide; chloroform; water
参考文献
Tanabe Seiyaku Co., Ltd.
Patent: US4886817 A1, 1989 ;
