3-(2,5,5-三甲基-1,3-二噁烷-2-基)-噻吩-2-磺酰胺合成路线 （共 3 条）
反应条件
hydrogenchloride in tetrahydrofuran 1 h; Reflux;
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: US2010/317655 A1, 2010 ;
Location in patent: Page/Page column 15 ;
反应条件
in tetrahydrofuran; hydrogenchloride
参考文献
Alcon Laboratories, Inc.
Patent: US5538966 A1, 1996 ;
反应条件
1: With n-butyllithium in hexane
T=-60 - 20°C; 3.25 h; Inert atmosphere;
2: With sulfur dioxide in tetrahydrofuran; hexane
T=-65 - 20°C; Inert atmosphere;
3: With NaOAc·3H2O; hydroxylamine-o-sulphonic acid in water
T=0 - 20°C;
参考文献
Sathe, Dhananjay Govind; Tarur, Radhakrishnan Venkatasubramanian; Bhise, Nandu Baban; Shinde, Ajit Bhaskar; Pardeshi, Santosh
Patent: US2010/9977 A1, 2010 ;
Location in patent: Page/Page column 10-11 ;
