2-(2-硝基苯胺基)-3-氰基-5-甲基噻吩合成路线 （共 10 条）
反应条件
sodium hydride in tetrahydrofuran; mineral oil T=20°C; 18 h; Inert atmosphereCooling with ice;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 7 p. 1953 - 1956
反应条件
tris(dibenzylideneacetone)dipalladium(0) chloroform complex; tetra-n-butylammonium acetate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in ethyl acetate T=50°C; Buchwald-Hartwig Coupling; TemperatureTimeSolvent;
参考文献
Hartwig, Jan; Ceylan, Sascha; Kupracz, Lukas; Coutable, Ludovic; Kirschning, Andreas
Angewandte Chemie - International Edition, 2013 , vol. 52, # 37 p. 9813 - 9817
Angew. Chem., 2013 , vol. 125, # 37 p. 9995 - 9999,5
反应条件
hydrogen in mesytilene T=160°C; 48 h; chemoselective reaction;
参考文献
Leyva-Perez, Antonio; Cabrero-Antonino, Jose R.; Corma, Avelino
Tetrahedron, 2010 , vol. 66, # 41 p. 8203 - 8209
反应条件
hydrogen in mesytilene T=160°C; 24 h; chemoselective reaction;
参考文献
Tetrahedron, , vol. 66, # 41 p. 8203 - 8209
反应条件
1: 65 percent / SnCl2; conc. HCl / ethanol / 1.5 h / Heating 2: 65 percent / dimethylsulfoxide; toluene / 24 h / Heating View Scheme
参考文献
Gao, Mingzhang; Shi, Zenas; Wang, Min; Zheng, Qi-Huang
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 7 p. 1953 - 1956
反应条件
hydrogen in mesytilene T=140°C; 48 h; chemoselective reaction;
参考文献
Tetrahedron, , vol. 66, # 41 p. 8203 - 8209
反应条件
1: SnCl2 / ethanol 2: toluene; dimethylsulfoxide / Heating View Scheme
参考文献
Gao, Mingzhang; Shi, Zenas; Wang, Min; Zheng, Qi-Huang
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 7 p. 1953 - 1956
反应条件
triethylsilane; palladium 10 on activated carbon in water; ethyl acetate
T=40°C; TemperatureTimeSolvent;
参考文献
Hartwig, Jan; Ceylan, Sascha; Kupracz, Lukas; Coutable, Ludovic; Kirschning, Andreas
Angewandte Chemie - International Edition, 2013 , vol. 52, # 37 p. 9813 - 9817
Angew. Chem., 2013 , vol. 125, # 37 p. 9995 - 9999,5
反应条件
hydrogen in mesytilene
T=140°C; 48 h; chemoselective reaction;
参考文献
Leyva-Perez, Antonio; Cabrero-Antonino, Jose R.; Corma, Avelino
Tetrahedron, 2010 , vol. 66, # 41 p. 8203 - 8209
反应条件
1: ethyl acetate
2: hydrogenchloride / isopropyl alcohol
View Scheme
参考文献
JANSSEN PHARMACEUTICA NV; ORTHO-CLINICAL DIAGNOSTICS, INC; DONAHUE, Matthew Garrett; GONG, Yong; SALTER, Rhys; HRYHORENKO, Eric; DECORY, Thomas R.; REMMERIE, Bart M.; SANKARAN, Banumathi
Patent: WO2014/31587 A1, 2014 ;
