1: With ammonia in water T=80°C; 5 h; 2: With hydrogenchloride in water T=0°C; pH=1;

1.1: ammonia / water / 5 h / 80 °C 1.2: 0 °C / pH 1 2.1: potassium hydroxide / water / 30 h / 0 °C 2.2: 1.17 h / 0 - 80 °C 2.3: 0.5 h / 80 - 90 °C View Scheme

1.1: ammonia / water / 5 h / 80 °C 1.2: 0 °C / pH 1 2.1: potassium hydroxide / water / 30 h / 0 °C 2.2: 1.17 h / 0 - 80 °C 2.3: 0.5 h / 80 - 90 °C View Scheme

1.1: ammonia / water / 5 h / 80 °C 1.2: 0 °C / pH 1 2.1: potassium hydroxide / water / 30 h / 0 °C 2.2: 1.17 h / 0 - 80 °C 2.3: 0.5 h / 80 - 90 °C View Scheme

<b>Multi-step reaction with 2 steps<br /> </b>1.1: chloroformic acid ethyl ester; triethylamine / acetone / -20 &deg;C / Inert atmosphere<br />1.2: 2 h / -20 &deg;C<br />1.3: 0 &deg;C<br />2.1: chloroform; ethanol / 0.75 h / 60 - 63 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1.1: acetyl chloride / 3.08 h / 20 - 55 &deg;C / Inert atmosphere<br />2.1: ammonia / water; tert-butyl methyl ether / 0 - 20 &deg;C<br />2.2: pH 2<br />3.1: chloroform; ethanol / 0.75 h / 60 - 63 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1.1: ammonia / water; tert-butyl methyl ether / 0 - 20 &deg;C<br />1.2: pH 2<br />2.1: chloroform; ethanol / 0.75 h / 60 - 63 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 5 steps<br /> </b>1.1: n-dipropylamine / 16 h / 15 - 55 &deg;C<br />2.1: hydrogen bromide / water / 72 h / 100 &deg;C<br />3.1: acetyl chloride / 3.08 h / 20 - 55 &deg;C / Inert atmosphere<br />4.1: ammonia / water; tert-butyl methyl ether / 0 - 20 &deg;C<br />4.2: pH 2<br />5.1: chloroform; ethanol / 0.75 h / 60 - 63 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 6 steps<br /> </b>1.1: piperidine; pyridine; acetic acid / hexane / 48 h / Reflux; Inert atmosphere<br />2.1: n-dipropylamine / 16 h / 15 - 55 &deg;C<br />3.1: hydrogen bromide / water / 72 h / 100 &deg;C<br />4.1: acetyl chloride / 3.08 h / 20 - 55 &deg;C / Inert atmosphere<br />5.1: ammonia / water; tert-butyl methyl ether / 0 - 20 &deg;C<br />5.2: pH 2<br />6.1: chloroform; ethanol / 0.75 h / 60 - 63 &deg;C<br /> <br /> &nbsp;