lithium hydroxide hydrate; water in tetrahydrofuran T=20°C; 19 h;

<b>Multi-step reaction with 2 steps<br /> </b>1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.58 h / 0 &deg;C<br />2: tetrachloromethane; triphenylphosphine / dichloromethane / 0.33 h / 20 - 50 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.33 h / -78 &deg;C<br />1.2: 16 h / -78 - 35 &deg;C<br />2.1: phenyl isocyanate; triethylamine / toluene / 4 h / 20 - 80 &deg;C<br />3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.58 h / 0 &deg;C<br />4.1: tetrachloromethane; triphenylphosphine / dichloromethane / 0.33 h / 20 - 50 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 6 steps<br /> </b>1.1: borane-THF / tetrahydrofuran / 14 h / -20 - 50 &deg;C / Reflux<br />2.1: 1H-imidazole / N,N-dimethyl-formamide / 1.75 h / 20 &deg;C<br />3.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.33 h / -78 &deg;C<br />3.2: 16 h / -78 - 35 &deg;C<br />4.1: phenyl isocyanate; triethylamine / toluene / 4 h / 20 - 80 &deg;C<br />5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.58 h / 0 &deg;C<br />6.1: tetrachloromethane; triphenylphosphine / dichloromethane / 0.33 h / 20 - 50 &deg;C<br /> <br /> &nbsp;