1: 51 percent / 70percent HNO3 / acetic acid / 1 h / 20 - 50 °C 2: H2 / 5percent Pd/C / tetrahydrofuran / 16 h / 2068.6 Torr 3: 75 percent / DIEA / dimethylformamide / a) 105 deg C, 1.5 h, b) 85 deg C, 1.5 h 4: 59 percent / DIEA / dimethylformamide / 1.42 h / 75 °C 5: Lawesson's reagent / toluene 6: NaOH / tetrahydrofuran; ethanol 7: NH3 / methanol View Scheme

1: NaOH / ethanol; H2O / 16 h / 25 °C 2: H2 / 5percent Pd/C / tetrahydrofuran / 16 h / 2068.6 Torr 3: 75 percent / DIEA / dimethylformamide / a) 105 deg C, 1.5 h, b) 85 deg C, 1.5 h 4: 59 percent / DIEA / dimethylformamide / 1.42 h / 75 °C 5: Lawesson's reagent / toluene 6: NaOH / tetrahydrofuran; ethanol 7: NH3 / methanol View Scheme

1: Na2CO3 / H2O / 1 h / Heating 2: NaOH / ethanol; H2O / 16 h / 25 °C 3: H2 / 5percent Pd/C / tetrahydrofuran / 16 h / 2068.6 Torr 4: 75 percent / DIEA / dimethylformamide / a) 105 deg C, 1.5 h, b) 85 deg C, 1.5 h 5: 59 percent / DIEA / dimethylformamide / 1.42 h / 75 °C 6: Lawesson's reagent / toluene 7: NaOH / tetrahydrofuran; ethanol 8: NH3 / methanol View Scheme

1: H2 / 5percent Pd/C / tetrahydrofuran / 16 h / 2068.6 Torr 2: 75 percent / DIEA / dimethylformamide / a) 105 deg C, 1.5 h, b) 85 deg C, 1.5 h 3: 59 percent / DIEA / dimethylformamide / 1.42 h / 75 °C 4: Lawesson's reagent / toluene 5: NaOH / tetrahydrofuran; ethanol 6: NH3 / methanol View Scheme

1: hydroxylamine hydrochloride, sodium acetate / H2O / 3 h / 80 °C 2: Na2CO3 / H2O / 1 h / Heating 3: NaOH / ethanol; H2O / 16 h / 25 °C 4: H2 / 5percent Pd/C / tetrahydrofuran / 16 h / 2068.6 Torr 5: 75 percent / DIEA / dimethylformamide / a) 105 deg C, 1.5 h, b) 85 deg C, 1.5 h 6: 59 percent / DIEA / dimethylformamide / 1.42 h / 75 °C 7: Lawesson's reagent / toluene 8: NaOH / tetrahydrofuran; ethanol 9: NH3 / methanol View Scheme

1: 48 percent / NBS / CCl4 / 1 h / Heating; Irradiation 2: 75 percent / DIEA / dimethylformamide / a) 105 deg C, 1.5 h, b) 85 deg C, 1.5 h 3: 59 percent / DIEA / dimethylformamide / 1.42 h / 75 °C 4: Lawesson's reagent / toluene 5: NaOH / tetrahydrofuran; ethanol 6: NH3 / methanol View Scheme

1: Lawesson's reagent / toluene 2: NaOH / tetrahydrofuran; ethanol 3: NH3 / methanol View Scheme

1: 75 percent / DIEA / dimethylformamide / a) 105 deg C, 1.5 h, b) 85 deg C, 1.5 h 2: 59 percent / DIEA / dimethylformamide / 1.42 h / 75 °C 3: Lawesson's reagent / toluene 4: NaOH / tetrahydrofuran; ethanol 5: NH3 / methanol View Scheme

1: 99 percent / CH2Cl2 / 2 h / 0 °C 2: 48 percent / NBS / CCl4 / 1 h / Heating; Irradiation 3: 75 percent / DIEA / dimethylformamide / a) 105 deg C, 1.5 h, b) 85 deg C, 1.5 h 4: 59 percent / DIEA / dimethylformamide / 1.42 h / 75 °C 5: Lawesson's reagent / toluene 6: NaOH / tetrahydrofuran; ethanol 7: NH3 / methanol View Scheme