1.1: toluene; tetrahydrofuran / 5 - 10 °C 1.3: 15 - 20 °C / pH 2 2.1: potassium carbonate / 1,1'-bis(di-tert-butylphosphino)ferrocene palladium dichloride / water; tetrahydrofuran / 32 h / 35 - 45 °C / Inert atmosphere 3.1: thionyl chloride / N,N-dimethyl-formamide / 10 - 20 °C 4.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 1 h / -15 °C 4.2: -10 °C View Scheme

1: in tetrahydrofuran; toluene T=5 - 10°C; 2: With sodium hydroxide in water 3: With sulfuric acid; water in isopropyl alcohol T=15 - 20°C; pH=2;

1.1: toluene; tetrahydrofuran / 5 - 10 °C 1.3: 15 - 20 °C / pH 2 2.1: potassium carbonate / 1,1'-bis(di-tert-butylphosphino)ferrocene palladium dichloride / water; tetrahydrofuran / 32 h / 35 - 45 °C / Inert atmosphere View Scheme