1: hydrogenchloride / tetrahydrofuran 2: sodium hydrogencarbonate 3: triethylamine / 0 °C 4: sodium hydride / N,N-dimethyl-formamide 5: hydrogenchloride / methanol View Scheme

<b>Multi-step reaction with 2 steps<br /> </b>1: titanium(IV) isopropylate; tert.-butylhydroperoxide; L-(+)-diisopropyl tartrate / dichloromethane / -20 &deg;C<br />2: methanesulfonyl chloride; triethylamine / 0 &deg;C / Reflux<br /> <br /> &nbsp;

<b>Multi-step reaction with 9 steps<br /> </b>1: sodium acetate / 0 &deg;C<br />2: potassium carbonate / acetone<br />3: lithium borohydride / ethanol / 20 &deg;C<br />4: Dess-Martin periodane<br />5: triphenylphosphine / dichloromethane<br />6: n-butyllithium / -78 &deg;C<br />7: hydrogen<br />8: titanium(IV) isopropylate; tert.-butylhydroperoxide; L-(+)-diisopropyl tartrate / dichloromethane / -20 &deg;C<br />9: methanesulfonyl chloride; triethylamine / 0 &deg;C / Reflux<br /> <br /> &nbsp;