6,7-二甲氧基喹唑啉-4-酮合成路线 （共 43 条）
参考文献
Bridges; Zhou; Cody; Rewcastle; McMichael; Showalter; Fry; Kraker; Denny
Journal of Medicinal Chemistry, 1996 , vol. 39, # 1 p. 267 - 276
参考文献
LeMahieu; Carson; Nason; Parrish; Welton; Baruth; Yaremko
Journal of Medicinal Chemistry, 1983 , vol. 26, # 3 p. 420 - 425
反应条件
in 2-methoxy-ethanol T=125°C; 8 h;
参考文献
European Journal of Medicinal Chemistry, , vol. 43, # 7 p. 1478 - 1488
反应条件
trimethyl orthoformate in methanol T=70°C; 4 h; Reflux;
参考文献
SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Jiancun; ZHANG, Yingjun; ZHANG, Weihong; LIU, Bing; ZHANG, Jiquan; LIU, Jinlei; ZHANG, Lu
Patent: WO2013/71697 A1, 2013 ;
Location in patent: Paragraph 00191 ;
参考文献
AstraZeneca AB
Patent: US7235559 B1, 2007 ;
US 7235559 B1
反应条件
in formamide T=190 - 200°C; 2 h;
参考文献
Cai, Xiong; Qian, Changgeng; Zhai, Haixiao; Bao, Rudi
Patent: US2009/111772 A1, 2009 ;
Location in patent: Page/Page column 54; 64 ;
US 20090111772 A1
反应条件
ammonia; acetic acid T=150°C; 2 h; Product distribution / selectivity;
参考文献
Mitsubishi Gas Chemical Company, Inc.
Patent: EP1997812 A1, 2008 ;
Location in patent: Page/Page column 6 ;
反应条件
ammonium acetate in methanol T=120°C; 3 h;
参考文献
Tran, Anh Thu; Wen, Daying; West, Nicholas P.; Baker, Edward N.; Britton, Warwick J.; Payne, Richard J.
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 46 p. 8113 - 8126
反应条件
sodium methylate; formamide in methanol; N,N-dimethyl-formamide 10 h; Heating;
参考文献
Furuta, Takayuki; Sakai, Teruyuki; Senga, Terufumi; Osawa, Tatsushi; Kubo, Kazuo; Shimizu, Toshiyuki; Suzuki, Rika; Yoshino, Tetsuya; Endo, Megumi; Miwa, Atsushi
Journal of Medicinal Chemistry, 2006 , vol. 49, # 7 p. 2186 - 2192
反应条件
1: 4,5-dimethoxy-2-nitrobenzonitrile With iron(III) chloride; hydrazine hydrate in methanol; water 3 h; Heating; 2: formic acid With hydrogenchloride in water T=130°C; 3 h; Further stages.;
参考文献
Chandregowda, Venkateshappa; Venkateswara Rao, Gudapati; Chandrasekara Reddy, Goukanapalli
Heterocycles, 2007 , vol. 71, # 1 p. 39 - 48
