1'-苄基-2,3-二氢螺[茚-1,4'-哌啶](2Z)-2-丁烯二酸酯(1:1)合成路线 （共 6 条）
参考文献
Regents of the University of Minnesota
Patent: US5457207 A1, 1995 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=100°C; 1 h;
参考文献
Chambers; Baker; Billington; Knight; Middlemiss; Wong
Journal of Medicinal Chemistry, 1992 , vol. 35, # 11 p. 2033 - 2039
反应条件
1: 65 percent / acetone / 48 h / Heating 2: 91 percent / NaBH4 / methanol / 1.67 h / 0 °C 3: 32 percent / 85 aq. H3PO4 / 80 h / Heating View Scheme
参考文献
Efange; Khare; Foulon; Akella; Parsons
Journal of Medicinal Chemistry, 1994 , vol. 37, # 16 p. 2574 - 2582
反应条件
1: 65 percent / acetone / 48 h / Heating 2: 91 percent / NaBH4 / methanol / 1.67 h / 0 °C 3: 32 percent / 85 aq. H3PO4 / 80 h / Heating View Scheme
参考文献
Efange; Khare; Foulon; Akella; Parsons
Journal of Medicinal Chemistry, 1994 , vol. 37, # 16 p. 2574 - 2582
反应条件
phosphoric acid 80 h; Heating;
参考文献
Efange; Khare; Foulon; Akella; Parsons
Journal of Medicinal Chemistry, 1994 , vol. 37, # 16 p. 2574 - 2582
反应条件
1-chloroethyl chlorocarbonate in 1,2-dichloro-ethane a) 0 deg C, 10 min, b) reflux, 1 h;
参考文献
Efange; Khare; Foulon; Akella; Parsons
Journal of Medicinal Chemistry, 1994 , vol. 37, # 16 p. 2574 - 2582
