hydrogen; palladium dihydroxide in ethyl acetate P=760 Torr; Ambient temperature;

<b>Multi-step reaction with 2 steps<br /> </b>1: 1.) NaH / 1.) DMF, 0 deg C, 2.) DMF, 120 deg C, 16 h<br />2: 88 percent / 4-dimethylaminopyridine, dicyclohexylcarbodiimide / CH₂Cl₂ / 8 h / Ambient temperature<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 1.) NaH, 2.) tetrabutylammonium bromide / 1.) THF, 0 deg C, 2.) THF, RT, 10 h<br />2: 1.) NaH / 1.) DMF, 0 deg C, 2.) DMF, 120 deg C, 16 h<br />3: 88 percent / 4-dimethylaminopyridine, dicyclohexylcarbodiimide / CH₂Cl₂ / 8 h / Ambient temperature<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 1.) NaH, 2.) tetrabutylammonium bromide / 1.) THF, 0 deg C, 2.) THF, RT, 10 h<br />2: 1.) NaH / 1.) DMF, 0 deg C, 2.) DMF, 120 deg C, 16 h<br />3: 88 percent / 4-dimethylaminopyridine, dicyclohexylcarbodiimide / CH₂Cl₂ / 8 h / Ambient temperature<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 1.) NaH / 1.) DMF, 0 deg C, 2.) DMF, 120 deg C, 16 h<br />2: 88 percent / 4-dimethylaminopyridine, dicyclohexylcarbodiimide / CH₂Cl₂ / 8 h / Ambient temperature<br /> <br /> &nbsp;