4-甲基-1,3-噻唑-2-甲醛合成路线 （共 14 条）
反应条件
n-butyllithium in tetrahydrofuran; N-methyl-acetamide; hexane
参考文献
PFIZER INC.
Patent: EP807633 A2, 1997 ;
反应条件
1: 4-methyl-thiazole With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 1 h; 2: N,N-dimethyl-formamide in tetrahydrofuran; hexane T=-78 - 20°C; 3 h;
参考文献
Lohre, Claudia; Froehlich, Roland; Glorius, Frank
Synthesis, 2008 , # 14 SPEC. ISS. art. no. C02008SS, p. 2221 - 2228
反应条件
n-butyllithium in hexane
参考文献
Sterling Winthrop Inc.
Patent: US5569655 A1, 1996 ;
反应条件
in diethyl ether T=-70°C;
参考文献
Acta Chemica Scandinavica (1947-1973), , vol. 20, p. 2649 - 2657
反应条件
ozone; ethyl acetate anschliessend Hydrieren an Palladium/Kohle;
参考文献
Yakugaku Zasshi, , vol. 57, p. 909,913; dtsch. Ref. S. 249, 252
Chem.Abstr., , p. 1699
反应条件
sodium carbonate; ethylene glycol
参考文献
Journal of Medicinal and Pharmaceutical Chemistry, , vol. 1, p. 577,594
反应条件
1: ZnCl2 / 180 °C 2: ethyl acetate; ozone / anschliessend Hydrieren an Palladium/Kohle View Scheme
参考文献
Yakugaku Zasshi, , vol. 57, p. 909,913; dtsch. Ref. S. 249, 252
Chem.Abstr., , p. 1699
反应条件
1: pyridine 2: Na2CO3; glass powder; ethylene glycol View Scheme
参考文献
Journal of Medicinal and Pharmaceutical Chemistry, , vol. 1, p. 577,594
反应条件
1: ethanol; N2H4+H2O 2: pyridine 3: Na2CO3; glass powder; ethylene glycol View Scheme
参考文献
Journal of Medicinal and Pharmaceutical Chemistry, , vol. 1, p. 577,594
反应条件
1: sodium tetrahydroborate; methanol / 0.75 h / 0 °C 2: triethylamine / dichloromethane / 0.33 h / 0 °C 3: sodium azide / N,N-dimethyl-formamide / 2 h / Reflux 4: hydrogen / palladium hydroxide on carbon / methanol View Scheme
参考文献
COMENTIS, INC.; ASTELLAS PHARMA INC.; BILCER, Geoffrey, M.; DEVASAMUDRAM, Thippeswamy; LILLY, John, C.; ANKALA, Sudha, V.; MOSKALEV, Nikolai, V.; LIU, Chunfeng; INOUE, Makoto; KAWAKAMI, Shimpei; MUNAKATA, Ryosuke; HAMAJIMA, Toshihiro
Patent: WO2012/54510 A1, 2012 ;
WO 2012/054510 A1
