4-甲基-5-(beta-羟乙基)噻唑合成路线 （共 90 条）
参考文献
Merck and Co. Inc.
Patent: US2235862 , 1938 ;
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Merck,E.
Patent: DE669187 , 1937 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 25, p. 457
参考文献
Rubzow et al.
Trudy vitamin. Inst.Chem.Abstr., 1954 , vol. 5, p. 10
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参考文献
Bahner et al.
Journal of the American Chemical Society, 1948 , vol. 70, p. 1652
参考文献
Bahner et al.
Journal of the American Chemical Society, 1948 , vol. 70, p. 1652
参考文献
Winthrop Chem. Co.
Patent: US2386766 , 1936 ;
反应条件
1: 4-methyl-5-thiazole ethanol With sodium hydride in tetrahydrofuran
0.666667 h; cooling;
2: ethyl iodide in tetrahydrofuran
T=20°C;
参考文献
Hamze, Abdallah; Rubi, Eric; Arnal, Pascal; Boisbrun, Michel; Carcel, Carole; Salom-Roig, Xavier; Maynadier, Marjorie; Wein, Sharon; Vial, Henri; Calas, Michele
Journal of Medicinal Chemistry, 2005 , vol. 48, # 10 p. 3639 - 3643
参考文献
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Journal of Biological Chemistry, 1947 , vol. 167, p. 699,701, 703
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Kenten
Biochemical Journal, 1958 , vol. 69, p. 439,440
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Matsukawa; Yurugi
Yakugaku Zasshi, 1952 , vol. 72, p. 990,994
Chem.Abstr., 1953 , p. 6420
反应条件
thionyl chloride in benzene
15 h;
参考文献
Bagley; Thomas; Rudo; Spencer; Doorley; Ossipov; Jerussi; Benvenga; Spaulding
Journal of Medicinal Chemistry, 1991 , vol. 34, # 2 p. 827 - 841
参考文献
Slobodin; Sigel'
Zhurnal Obshchei Khimii, 1941 , vol. 11, p. 1019,1021
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参考文献
Stein et al.
Journal of the American Chemical Society, 1941 , vol. 63, p. 2059,2062
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Winthrop Chem. Co.
Patent: US2386766 , 1936 ;
Full Text Show Details
I.G. Farbenind.
Patent: DE685032 , 1939 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 24, p. 446
