3,5-二氯-2-哌嗪甲醛合成路线 （共 5 条）
反应条件
1: 2,6-dichloropyrazine With 2,2,6,6-tetramethyl-piperidine; n-butyllithium in tetrahydrofuran T=-78°C; 2: formic acid ethyl ester in tetrahydrofuran T=-78°C; 2 h;
参考文献
PFIZER INC.; NINKOVIC, Sacha; BRAGANZA, John Frederick; COLLINS, Michael Raymond; KATH, John Charles; LI, Hui; RICHTER, Daniel Tyler
Patent: WO2010/16005 A1, 2010 ;
Location in patent: Page/Page column 111-112 ;
WO 2010/016005 A1
反应条件
n-butyllithium in tetrahydrofuran; hexane; ethyl acetate
参考文献
US2003/220348 A1, ;
US 20030220348 A1
反应条件
in tetrahydrofuran T=-70°C; 2 h; var. time, solv.; other electrophiles, 2,6-dimethoxypyrazine; Product distribution;
参考文献
Journal of Organometallic Chemistry, , vol. 412, # 3 p. 301 - 310
反应条件
sodium methylate in methanol
参考文献
Neurogen Corporation
Patent: US2003/220348 A1, 2003 ;
US 20030220348 A1
反应条件
sodium methylate in methanol
参考文献
Neurogen Corporation
Patent: US2003/220348 A1, 2003 ;
US 20030220348 A1
