1-[(2R,3S,4R,5R)-3-氟-4-羟基-5-(羟基甲基)四氢呋喃-2-基]嘧啶-2-酮合成路线 （共 3 条）
反应条件
methanol; ammonia T=0°C; 1.5 h;
参考文献
Driscoll, John S.; Marquez, Victor E.; Plowman, Jacqueline; Liu, Paul S.; Kelley, James A.; Barchi, Joseph J.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 11 p. 3280 - 3284
反应条件
1: 1,2-dichloro-ethane / 18 h / Heating 2: 55 percent / NH3/MeOH / 1.5 h / 0 °C View Scheme
参考文献
Driscoll, John S.; Marquez, Victor E.; Plowman, Jacqueline; Liu, Paul S.; Kelley, James A.; Barchi, Joseph J.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 11 p. 3280 - 3284
反应条件
1: 93 percent / HBr/acetic acid / CH2Cl2 / Ambient temperature 2: 1,2-dichloro-ethane / 18 h / Heating 3: 55 percent / NH3/MeOH / 1.5 h / 0 °C View Scheme
参考文献
Driscoll, John S.; Marquez, Victor E.; Plowman, Jacqueline; Liu, Paul S.; Kelley, James A.; Barchi, Joseph J.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 11 p. 3280 - 3284
