2-甲基苯并[d]噁唑-6-羧酸甲酯合成路线 （共 10 条）
反应条件
1: With trifluoroacetic acid T=20°C; 1.5 h; 2: With sodium hydrogencarbonate in dichloromethane; water
参考文献
METHYLGENE INC.
Patent: WO2007/118137 A1, 2007 ;
Location in patent: Page/Page column 108 ;
反应条件
pyridinium p-toluenesulfonate; triethylamine in xylene 8.5 h; Heating / reflux;
参考文献
Eisai Co., Ltd.
Patent: EP1669348 A1, 2006 ;
Location in patent: Page/Page column 68 ;
参考文献
McElhinny Jr., Charles J.; Lewin, Anita H.; Mascarella, S. Wayne; Runyon, Scott; Brieaddy, Lawrence; Carroll, F. Ivy
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 21 p. 6661 - 6664
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2005/82901 A1, 2005 ;
Location in patent: Page/Page column 33; 61 ;
反应条件
sulfuric acid in methanol; water; ethyl acetate; methyl 4-amino-3-hydroxy-benzoate
参考文献
Rohm and Haas Company
Patent: US5811427 A1, 1998 ;
参考文献
Nishioka, Hiromi; Ohmori, Yukiko; Iba, Yumiko; Tsuda, Eri; Harayama, Takashi
Heterocycles, 2004 , vol. 64, p. 193 - 198
参考文献
Perrey, David A.; Gilmour, Brian P.; Runyon, Scott P.; Thomas, Brian F.; Zhang, Yanan
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 10 p. 2980 - 2985
反应条件
1: benzene 2: zinc chloride / 160 °C View Scheme
参考文献
v. Meyer
Journal fuer Praktische Chemie (Leipzig), 1915 , vol. <2> 92, p. 265
反应条件
1: With methanol; potassium hydroxide; water in tetrahydrofuran T=20°C; 1.08333 h; 2: With hydrogenchloride in tetrahydrofuran; methanol; water pH=2.5;
参考文献
METHYLGENE INC.
Patent: WO2007/118137 A1, 2007 ;
Location in patent: Page/Page column 109 ;
反应条件
1: With sodium hydroxide in ethanol; water T=20°C; 2 h; 2: With hydrogenchloride in ethanol; water pH=4;
参考文献
Eisai Co., Ltd.
Patent: EP1669348 A1, 2006 ;
Location in patent: Page/Page column 68 ;
