2,2'-二氨基-4,4'-二溴联苯合成路线 （共 12 条）
反应条件
hydrogenchloride; tin in ethanol 0.5 h;
参考文献
Yamato, Takehiko; Hideshima, Chieko; Suehiro, Kazuaki; Tashiro, Masashi; Prakash, G. K. Surya; Olah, George A.
Journal of Organic Chemistry, 1991 , vol. 56, # 21 p. 6248 - 6250
反应条件
1: With copper in N,N-dimethyl-formamide T=120°C; 2 h; 2: With hydrogenchloride; tin in ethanol 1 h; Heating;
参考文献
Li, Chien-Le; Shieh, Shwu-Ju; Lin, Shien-Chang; Liu, Rai-Shung
Organic Letters, 2003 , vol. 5, # 7 p. 1131 - 1134
反应条件
tin(ll) chloride in ethanol 3 h; Heating;
参考文献
Patrick; Boykin; Wilson; Tanious; Spychala; Bender; Hall; Dykstra; Ohemeng; Tidwell
European Journal of Medicinal Chemistry, 1997 , vol. 32, # 10 p. 781 - 793
反应条件
1: nitric acid / 0.67 h / 0 °C 2: conc. HCl; Sn / ethanol / 0.5 h / Heating View Scheme
参考文献
Price Jr., David W.; Tour, James M.
Tetrahedron, 2003 , vol. 59, # 17 p. 3131 - 3156
参考文献
Le Fevre
Journal of the Chemical Society, 1929 , p. 737
参考文献
Kim, Ji Eun; Lee, Jae Chol; Kim, Kong Kyeom; Bae, Jae Soon; Jang, Jun Gi; Jeon, Sang Young; Kang, Min Soo; Cho, Wook Dong; Jeon, Byung Sun; Kim, Yeon Hwan
Patent: US2005/225235 A1, 2005 ;
反应条件
in phosphoric acid T=190 - 200°C; 26 h;
参考文献
Patrick; Boykin; Wilson; Tanious; Spychala; Bender; Hall; Dykstra; Ohemeng; Tidwell
European Journal of Medicinal Chemistry, 1997 , vol. 32, # 10 p. 781 - 793
反应条件
1: With hydrogenchloride; sodium nitrite in water; acetonitrile
T=-10 - -5°C; 1 h; Inert atmosphere;
2: With potassium iodide in water; acetonitrile
T=80°C; Sandmeyer reaction; 20 h; Inert atmosphere;
参考文献
Keyworth, Colin W.; Chan, Khai Leok; Labram, John G.; Anthopoulos, Thomas D.; Watkins, Scott E.; McKiernan, Mary; White, Andrew J. P.; Holmes, Andrew B.; Williams, Charlotte K.
Journal of Materials Chemistry, 2011 , vol. 21, # 32 p. 11800 - 11814
反应条件
1.1: nitrosylsulfuric acid; sulfuric acid / 3 h
1.2: 30 percent / aq. KI / 20 °C
2.1: t-butyllithium / tetrahydrofuran; pentane / 3 h / -90 °C
2.2: 52 percent / tetrahydrofuran; pentane / -90 - 20 °C
View Scheme
参考文献
Chan, Khai Leok; McKiernan, Mary J.; Towns, Carl R.; Holmes, Andrew B.
Journal of the American Chemical Society, 2005 , vol. 127, # 21 p. 7662 - 7663
反应条件
1.1: HCl; NaNO2 / H2O / 30 h / 0 °C
1.2: 28 percent / KI / H2O / -5 - 20 °C
2.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C
2.2: 70 percent / hexane; tetrahydrofuran / -78 - 20 °C
View Scheme
参考文献
Usta, Hakan; Lu, Gang; Facchetti, Antonio; Marks, Tobin J.
Journal of the American Chemical Society, 2006 , vol. 128, # 28 p. 9034 - 9035
