2,7-二叔丁基-9-芴基甲醇合成路线 （共 4 条）
反应条件
in dichloromethane; toluene T=20°C; chloroacylation; 72 h;
参考文献
Stigers, Kimberly D.; Koutroulis, Mathew R.; Chung, De Michael; Nowick, James S.
Journal of Organic Chemistry, 2000 , vol. 65, # 12 p. 3858 - 3859
参考文献
Chinchilla, Rafael; Dodsworth, David J; Najera, Carmen; Soriano, Jose M
Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 14 p. 1817 - 1820
反应条件
1: 2,7-tBu2-fluorene With n-butyllithium in tetrahydrofuran; hexane
T=0 - 5°C; Metallation; 0.133333 h;
2: formaldehyd in tetrahydrofuran; hexane
T=0 - 20°C; hydroxymethylation; 0.833333 h; Further stages.;
参考文献
Stigers, Kimberly D.; Koutroulis, Mathew R.; Chung, De Michael; Nowick, James S.
Journal of Organic Chemistry, 2000 , vol. 65, # 12 p. 3858 - 3859
反应条件
1.1: 93 percent / FeCl3 / CS2 / 0 - 20 °C
2.1: n-BuLi / tetrahydrofuran; hexane / 0.13 h / 0 - 5 °C
2.2: 63 percent / tetrahydrofuran; hexane / 0.83 h / 0 - 20 °C
View Scheme
参考文献
Stigers, Kimberly D.; Koutroulis, Mathew R.; Chung, De Michael; Nowick, James S.
Journal of Organic Chemistry, 2000 , vol. 65, # 12 p. 3858 - 3859
