5-(4-(2-(5-乙基吡啶-2-基)乙氧基)苯亚甲基)噻唑烷-2,4-二酮合成路线 （共 7 条）
反应条件
1: 67 percent / NaH (oil susp.) / tetrahydrofuran 2: 70 percent / Raney Ni, aq. HCOOH / Heating 3: 64 percent / piperidine / ethanol / Heating 4: acetonitrile / 0.75 h / Irradiation View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 39, # 6 p. 1440 - 1445
反应条件
1: 1.) p-toluenesulfonyl chloride, aq. NaOH; 2.) aq. NaOH / 1.) benzyltributylammonium chloride / 1.) H2O, CH2Cl2, r.t., 2 h; 2.) H2O, 40-50 deg C, 12 h 2: 64 percent / piperidine / ethanol / Heating 3: acetonitrile / 0.75 h / Irradiation View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 39, # 6 p. 1440 - 1445
反应条件
1: 67 percent / NaH (oil susp.) / tetrahydrofuran 2: 70 percent / Raney Ni, aq. HCOOH / Heating 3: 64 percent / piperidine / ethanol / Heating 4: acetonitrile / 0.75 h / Irradiation View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 39, # 6 p. 1440 - 1445
反应条件
1: 64 percent / piperidine / ethanol / Heating 2: acetonitrile / 0.75 h / Irradiation View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 39, # 6 p. 1440 - 1445
反应条件
1: 70 percent / Raney Ni, aq. HCOOH / Heating 2: 64 percent / piperidine / ethanol / Heating 3: acetonitrile / 0.75 h / Irradiation View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 39, # 6 p. 1440 - 1445
反应条件
in acetonitrile 0.75 h; Irradiation;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 39, # 6 p. 1440 - 1445
反应条件
sodium tetrahydroborate; butane-2,3-dione-bis-methylimine; sodium hydroxide; cobaltous chloride hexahydrate in polyethylene glycol-400 (PEG-400); water; N,N-dimethyl-formamide T=0 - 15°C;
参考文献
BIOCON LIMITED
Patent: WO2009/104200 A1, 2009 ;
Location in patent: Page/Page column 7-8 ;
