(5Z)-5-{4-[2-(5-乙基-2-吡啶基)乙氧基]亚苄基}-1,3-噻唑烷-2,4-二酮合成路线 （共 11 条）
反应条件
pyrrolidine in methanol T=10 - 50°C; 8 h;
参考文献
SANDOZ AG
Patent: WO2005/49610 A1, 2005 ;
Location in patent: Page/Page column 16 ;
反应条件
trichlorophosphate in toluene 8 h; Reflux;
参考文献
Mohanty, Sandeep; Reddy. G, Sandeep; Karmakar, Arun Chandra
Letters in Organic Chemistry, 2014 , vol. 11, # 3 p. 197 - 202
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP257781 B1, 1991 ;
反应条件
1: 1.) p-toluenesulfonyl chloride, aq. NaOH; 2.) aq. NaOH / 1.) benzyltributylammonium chloride / 1.) H2O, CH2Cl2, r.t., 2 h; 2.) H2O, 40-50 deg C, 12 h 2: 64 percent / piperidine / ethanol / Heating View Scheme
参考文献
Mohanty, Sandeep; Reddy. G, Sandeep; Karmakar, Arun Chandra
Letters in Organic Chemistry, 2014 , vol. 11, # 3 p. 197 - 202
反应条件
1: 67 percent / NaH (oil susp.) / tetrahydrofuran 2: 70 percent / Raney Ni, aq. HCOOH / Heating 3: 64 percent / piperidine / ethanol / Heating View Scheme
参考文献
Momose; Meguro; Ikeda; Hatanaka; Oi; Sohda
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 6 p. 1440 - 1445
反应条件
1: 67 percent / NaH (oil susp.) / tetrahydrofuran 2: 70 percent / Raney Ni, aq. HCOOH / Heating 3: 64 percent / piperidine / ethanol / Heating View Scheme
参考文献
Momose; Meguro; Ikeda; Hatanaka; Oi; Sohda
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 6 p. 1440 - 1445
反应条件
1: 70 percent / Raney Ni, aq. HCOOH / Heating 2: 64 percent / piperidine / ethanol / Heating View Scheme
参考文献
Momose; Meguro; Ikeda; Hatanaka; Oi; Sohda
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 6 p. 1440 - 1445
反应条件
1: potassium carbonate / toluene / |Reflux 2: sodium hydrogensulfite / water; hexane 3: trichlorophosphate / toluene / 8 h / |Reflux View Scheme
参考文献
Mohanty, Sandeep; Reddy. G, Sandeep; Karmakar, Arun Chandra
Letters in Organic Chemistry, 2014 , vol. 11, # 3 p. 197 - 202
反应条件
1: sodium hydrogensulfite / water; hexane 2: trichlorophosphate / toluene / 8 h / |Reflux View Scheme
参考文献
Mohanty, Sandeep; Reddy. G, Sandeep; Karmakar, Arun Chandra
Letters in Organic Chemistry, 2014 , vol. 11, # 3 p. 197 - 202
反应条件
in acetonitrile 0.75 h; Irradiation;
参考文献
Momose; Meguro; Ikeda; Hatanaka; Oi; Sohda
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 6 p. 1440 - 1445
