5-甲氧基-1,2,3,4-四氢-N-(苯甲基)-2-萘胺合成路线 （共 7 条）
反应条件
1: With acetic acid in dichloromethane T=20°C; 4 h; 2: With sodium tris(acetoxy)borohydride in dichloromethane T=0 - 20°C; 15.5 h; 3: With water; sodium hydrogencarbonate in dichloromethane T=0°C; pH=8.0; 0.25 h;
参考文献
Laboratorios del Dr. Esteve S.A.
Patent: EP1997493 A1, 2008 ;
Location in patent: Page/Page column 44-45; 53 ;
EP 1997493 A1
反应条件
1: p-TsOH*H2O / benzene / 17 h / Heating 2: H2 / PtO2 / ethanol / 2.5 h / 1520 Torr View Scheme
参考文献
Copinga, Swier; Tepper, Pieter G.; Grol, Cor J.; Horn, Alan S.; Dubocovich, Margarita L.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 20 p. 2891 - 2898
反应条件
1: 2N aq. NaOH / 1.) 55 deg C, 2 h, 2.) reflux 2 h 2: 1.) Na, EtOH, 2.) 2N aq. HCl / 1.) reflux, 1 h, 2.) EtOH, reflux, 30 min 3: p-TsOH*H2O / benzene / 17 h / Heating 4: H2 / PtO2 / ethanol / 2.5 h / 1520 Torr View Scheme
参考文献
Copinga, Swier; Tepper, Pieter G.; Grol, Cor J.; Horn, Alan S.; Dubocovich, Margarita L.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 20 p. 2891 - 2898
反应条件
1: 1.) Na, EtOH, 2.) 2N aq. HCl / 1.) reflux, 1 h, 2.) EtOH, reflux, 30 min 2: p-TsOH*H2O / benzene / 17 h / Heating 3: H2 / PtO2 / ethanol / 2.5 h / 1520 Torr View Scheme
参考文献
Copinga, Swier; Tepper, Pieter G.; Grol, Cor J.; Horn, Alan S.; Dubocovich, Margarita L.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 20 p. 2891 - 2898
参考文献
Bakthavachalam, Venkatesalu; Baindur, Nandkishore; Madras, Bertha K.; Neumeyer, John L.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 11 p. 3235 - 3241
参考文献
Bakthavachalam, Venkatesalu; Baindur, Nandkishore; Madras, Bertha K.; Neumeyer, John L.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 11 p. 3235 - 3241
反应条件
hydrogen; palladium on activated charcoal in ethanol
T=45°C; P=2280 Torr; 1 h;
参考文献
Copinga, Swier; Tepper, Pieter G.; Grol, Cor J.; Horn, Alan S.; Dubocovich, Margarita L.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 20 p. 2891 - 2898
