4,5,6,7-四氢吲哚合成路线 （共 40 条）
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=75 - 80°C; 26.5 h; RefluxInert atmosphere; 2: With water; sodium hydroxide in ethyl acetate 0.5 h;
参考文献
THE JOHNS HOPKINS UNIVERSITY; THE SCRIPPS RESEARCH INSTITUTE; ZACK, Donald, Jeffrey; BANNISTER, Thomas; VOJKOVSKY, Tomas; YANG, Zhiyong; BERLINICKE, Cynthia
Patent: WO2011/119777 A2, 2011 ;
Location in patent: Page/Page column 35-36 ;
WO 2011/119777 A2
反应条件
hydrogen; silica gel; ruthenium in octane T=100°C; P=22501.8 Torr; 1 h;
参考文献
Journal of Catalysis, , vol. 213, # 1 p. 47 - 62
反应条件
5 Ru/MgO; hydrogen in tetrahydrofuran T=150°C; P=38002.6 Torr; 0.4 h;
参考文献
Journal of Catalysis, , vol. 311, p. 357 - 368
反应条件
ammonia; lithium in methanol T=-40 - 20°C; Birch reduction;
参考文献
Tetrahedron, , vol. 61, # 9 p. 2401 - 2405
反应条件
ammonium hydroxide in ethanol T=150°C;
参考文献
Lee, Chang Kiu; Lee, In-Sook Han; Noland, Wayland
Heterocycles, 2007 , vol. 71, # 2 p. 419 - 428
反应条件
hydrogen; Rh on carbon T=180°C; P=60006 Torr; 4 h;
参考文献
New Journal of Chemistry, , vol. 32, # 6 p. 1027 - 1037
反应条件
hydrogen; ruthenium(IV) oxide T=125 - 180°C; P=52505.3 Torr; 6 h;
参考文献
New Journal of Chemistry, , vol. 32, # 6 p. 1027 - 1037
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 3 h; Heating;
参考文献
De Kimpe, Norbert; Keppens, Marian
Tetrahedron, 1996 , vol. 52, # 10 p. 3705 - 3718
反应条件
hydrogen; nickel in methanol; water P=3102.9 Torr; 120 h; Ambient temperature; Yield given;
参考文献
Journal of Heterocyclic Chemistry, , vol. 25, p. 1135 - 1137
反应条件
rubidium hydroxide in dimethyl sulfoxide T=120°C; 2 h; rotating steel autoclave;
参考文献
Mikhaleva, A. I.; Vasil'ev, A. N.; Trofimov, B. A.
Journal of Organic Chemistry USSR (English Translation), 1981 , vol. 17, # 9 p. 1763 - 1766
Zhurnal Organicheskoi Khimii, 1981 , vol. 17, # 9 p. 1977 - 1980
