1.1: (R)-diphenylprolinol trimethylsilyl ether / ethanol / 16 h / 0 °C 2.1: sodium dihydrogenphosphate; sodium chlorite / 2-methyl-but-2-ene; water; tert-butyl alcohol / 3 h / 20 °C 3.1: thionyl chloride / dichloromethane / 2 h / 60 °C 3.2: 16 h / 0 - 20 °C 4.1: palladium 10 on activated carbon; hydrogen / methanol / 5 h / 20 °C 5.1: sodium hydroxide / methanol; water / 2 h / Reflux 5.2: 0.5 h / 160 °C / Inert atmosphere 6.1: thionyl chloride / toluene / 2 h / 60 °C 7.1: ammonia / dichloromethane / 0.17 h 8.1: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / 0 - 20 °C 9.1: triethylamine / dichloromethane / 1 h / 20 °C View Scheme