(7alpha,12alpha)-7,12-二羟基-3-氧代胆-4-烯-24-酸合成路线 （共 8 条）
反应条件
1: 1.) Li/NH3 2: 86 percent / 4-dimethylaminopyridine / benzene; pyridine / 0.08 h / Ambient temperature 3: 96 percent / K2CrO4 / acetic acid; H2O / Ambient temperature 4: 100 percent / KOH / methanol / 12 h / Heating 5: p-toluenesulfonic acid / Ambient temperature 6: 88 percent / pyridine / 24 h / Ambient temperature 7: 95 percent / 65 h / 80 °C 8: 83 percent / alumina / benzene / 18 h 9: 76 percent / NaBH4, PdCl2 / methanol / 2 h / Ambient temperature 10: KOH / methanol / 1 h / Heating View Scheme
参考文献
Iida, Takashi; Shinohara, Toshiyuki; Momose, Toshiaki; Tamura, Toshitake; Matsumoto, Taro; et al.
Synthesis, 1986 , # 12 p. 998 - 1004
反应条件
ammonia; lithium Yield given. Multistep reaction;
参考文献
Iida, Takashi; Momose, Toshiaki; Chang, Frederic C.; Nambara, Toshio
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 5 p. 1934 - 1938
反应条件
1: 1.) Li/NH3 2: 86 percent / 4-dimethylaminopyridine / benzene; pyridine / 0.08 h / Ambient temperature 3: 96 percent / K2CrO4 / acetic acid; H2O / Ambient temperature 4: 100 percent / KOH / methanol / 12 h / Heating 5: p-toluenesulfonic acid / Ambient temperature 6: 88 percent / pyridine / 24 h / Ambient temperature 7: 95 percent / 65 h / 80 °C 8: 83 percent / alumina / benzene / 18 h 9: 76 percent / NaBH4, PdCl2 / methanol / 2 h / Ambient temperature 10: KOH / methanol / 1 h / Heating View Scheme
参考文献
Iida, Takashi; Shinohara, Toshiyuki; Momose, Toshiaki; Tamura, Toshitake; Matsumoto, Taro; et al.
Synthesis, 1986 , # 12 p. 998 - 1004
反应条件
Multi-step reaction with 2 steps 1: acetic acid; bromine2: pyridine
参考文献
Kazuno; Baba Proceedings of the Japan Academy, 1951 , vol. 27, p. 255,261
反应条件
Multi-step reaction with 2 steps 1: 1.) Li/NH3 2: 86 percent / 4-dimethylaminopyridine / benzene; pyridine / 0.08 h / Ambient temperature
参考文献
Iida, Takashi; Shinohara, Toshiyuki; Momose, Toshiaki; Tamura, Toshitake; Matsumoto, Taro; et al. Synthesis, 1986 , # 12 p. 998 - 1004
反应条件
Multi-step reaction with 3 steps 1: 1.) Li/NH3 2: 86 percent / 4-dimethylaminopyridine / benzene; pyridine / 0.08 h / Ambient temperature3: 96 percent / K2CrO4 / acetic acid; H2O / Ambient temperature
参考文献
Iida, Takashi; Shinohara, Toshiyuki; Momose, Toshiaki; Tamura, Toshitake; Matsumoto, Taro; et al. Synthesis, 1986 , # 12 p. 998 - 1004
反应条件
Multi-step reaction with 6 steps 1: 1.) Li/NH3 2: 86 percent / 4-dimethylaminopyridine / benzene; pyridine / 0.08 h / Ambient temperature3: 96 percent / K2CrO4 / acetic acid; H2O / Ambient temperature4: 100 percent / KOH / methanol / 12 h / Heating5: p-toluenesulfonic acid / Ambient temperature6: 88 percent / pyridine / 24 h / Ambient temperature
参考文献
Iida, Takashi; Shinohara, Toshiyuki; Momose, Toshiaki; Tamura, Toshitake; Matsumoto, Taro; et al. Synthesis, 1986 , # 12 p. 998 - 1004
反应条件
Multi-step reaction with 7 steps 1: 1.) Li/NH3 2: 86 percent / 4-dimethylaminopyridine / benzene; pyridine / 0.08 h / Ambient temperature3: 96 percent / K2CrO4 / acetic acid; H2O / Ambient temperature4: 100 percent / KOH / methanol / 12 h / Heating5: p-toluenesulfonic acid / Ambient temperature6: 88 percent / pyridine / 24 h / Ambient temperature7: 95 percent / 65 h / 80 °C
参考文献
Iida, Takashi; Shinohara, Toshiyuki; Momose, Toshiaki; Tamura, Toshitake; Matsumoto, Taro; et al. Synthesis, 1986 , # 12 p. 998 - 1004
