3,N-二甲基-N-甲氧基苯甲酰胺合成路线 （共 7 条）
反应条件
1: meta-methylbenzoic acid With 1,1'-carbonyldiimidazole in dichloromethane T=0°C; 0.5 h; 2: O,N-dimethyl-hydroxylamine hydrochloride With triethylamine in dichloromethane T=0 - 20°C;
参考文献
Gembus, Vincent; Furman, Christophe; Millet, Regis; Mansouri, Roxane; Chavatte, Philippe; Levacher, Vincent; Briere, Jean-Francois
European Journal of Medicinal Chemistry, 2012 , vol. 58, p. 396 - 404
反应条件
1: O,N-dimethyl-hydroxylamine hydrochloride With triethylamine in dichloromethane T=0°C; Inert atmosphere; 2: 3-methylbenzoic acid chloride in dichloromethane T=0 - 20°C; Inert atmosphere;
参考文献
Kishore Kumar; Chavarria, Gustavo E.; Charlton-Sevcik, Amanda K.; Arispe, Wara M.; MacDonough, Matthew T.; Strecker, Tracy E.; Chen, Shen-En; Siim, Bronwyn G.; Chaplin, David J.; Trawick, Mary Lynn; Pinney, Kevin G.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 4 p. 1415 - 1419
反应条件
1: SOCl2 / toluene; dimethylformamide / 2 h / Heating 2: 1.72 g / pyridine / CH2Cl2 View Scheme
参考文献
Ottosen, Erik Rytter; Sorensen, Morten Dahl; Bjoerkling, Fredrik; Skak-Nielsen, Tine; Fjording, Marianne Scheel; Aaes, Helle; Binderup, Lise
Journal of Medicinal Chemistry, 2003 , vol. 46, # 26 p. 5651 - 5662
反应条件
in tetrahydrofuran T=-78°C; 3 h;
参考文献
ALLERGAN, INC.
Patent: US2007/270498 A1, 2007 ;
Location in patent: Page/Page column 24 ;
反应条件
1: With diisobutylaluminium hydride in tetrahydrofuran; hexane T=-78°C; 1.5 h; Inert atmosphere; 2: With ammonia; iodine in tetrahydrofuran; hexane; water T=0 - 20°C; Inert atmosphere;
参考文献
Suzuki, Yusuke; Yoshino, Takumi; Moriyama, Katsuhiko; Togo, Hideo
Tetrahedron, 2011 , vol. 67, # 21 p. 3809 - 3814
反应条件
in tetrahydrofuran T=0 - 20°C; 4 h;
参考文献
ABBVIE INC.; BAYBURT, Erol K.; CLAPHAM, Bruce; COX, Phil B.; DAANEN, Jerome F.; GOMTSYAN, Arthur; KORT, Michael E.; KYM, Philip R.; VOIGHT, Eric A.; SCHMIDT, Robert G.; DART, Michael J.; GFESSER, Gregory
Patent: WO2013/62966 A2, 2013 ;
Location in patent: Paragraph 133; 134 ;
反应条件
in tetrahydrofuran
T=20°C; 2 h; Cooling with ice;
参考文献
Gembus, Vincent; Furman, Christophe; Millet, Regis; Mansouri, Roxane; Chavatte, Philippe; Levacher, Vincent; Briere, Jean-Francois
European Journal of Medicinal Chemistry, 2012 , vol. 58, p. 396 - 404
