2-氨基-4-溴苯甲酸甲酯合成路线 （共 13 条）
反应条件
1: With hydrogenchloride T=20°C; 24 h; 2: With sodium hydrogencarbonate in water
参考文献
PFIZER PRODUCTS INC.
Patent: WO2006/48727 A1, 2006 ;
Location in patent: Page/Page column 77 ;
WO 2006/048727 A1
反应条件
hydrogen; palladium on activated carbon in methanol P=2585.81 Torr; 1 h;
参考文献
NEUROTUNE AG; AHMED, Shaheen; HETTWER, Stefan; VRIJBLOED, Jan Willem; FARINA, Carlo; ALLGEIER, Hans
Patent: WO2012/59442 A2, 2012 ;
Location in patent: Page/Page column 111 ;
WO 2012/059442 A2
反应条件
anhydrous sodium hydrogen carbonate; acetic acid in methanol; hexane; ethyl acetate
参考文献
EP1820795 A1, ;
EP 1820795 A1
反应条件
diphenylphosphoranyl azide; triethylamine in methanol; water; ethyl acetate; acetone; toluene
反应条件
1: methanol With iodobenzene; toluene-4-sulfonic acid; sodium sulfate; 3-chloro-benzenecarboperoxoic acid T=0°C; 0.166667 h; Inert atmosphere; 2: 5-bromo-1,3-dihydro-1,3-dioxo-2H-isoindole With 1,8-diazabicyclo[5.4.0]undec-7-ene T=0 - 40°C; Hofmann-type rearrangement; 5 h; Inert atmosphere; regioselective reaction;
参考文献
Organic Letters, , vol. 14, # 3 p. 946 - 949
反应条件
1.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 3 h / 50 °C 1.2: pH 2 2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.5 h / 20 °C 2.2: 15 h / 20 °C View Scheme
参考文献
TIBOTEC PHARMACEUTICALS; VANDYCK, Koen; VERSCHUEREN, Wim Gaston; RABOISSON, Pierre Jean-Marie Bernard
Patent: WO2012/13643 A1, 2012 ;
反应条件
1: With water; sodium hydroxide in tetrahydrofuran; ethanol T=50°C; 3 h; 2: With hydrogenchloride in water pH=2;
参考文献
WO2012/13643 A1, ;
Page/Page column 48 ;
反应条件
1: acetic acid / 22 h / 20 °C 2: trichlorophosphate; N-ethyl-N,N-diisopropylamine / 36 h / 20 °C / |Reflux View Scheme
参考文献
MERCK PATENT GMBH; Mederski, Werner; Fuchss, Thomas; Zenke, Frank
Patent: US2013/12489 A1, 2013 ;
反应条件
acetic acid T=20°C; 22 h;
参考文献
MERCK PATENT GMBH; Mederski, Werner; Fuchss, Thomas; Zenke, Frank
Patent: US2013/12489 A1, 2013 ;
Location in patent: Paragraph 0173 ;
反应条件
1: With sulfuric acid; sodium nitrite in water
0.666667 h; Cooling with ice;
2: With sulfuric acid; potassium iodide in water
T=5°C; 2 h;
参考文献
Mitsubishi Tanabe Pharma Corporation; MAEDA, Kazuhiro; ENDOH, Jun-ichi; TARAO, Akiko; TASHIRO, Kaoru; ISHIBUCHI, Seigo; HIKAWA, Hidemasa
Patent: EP2565182 A1, 2013 ;
Location in patent: Paragraph 0360; 0361; 0362 ;
