N-chloro-succinimide; potassium bromide in methanol; acetic acid T=20 - 60°C; 4.33 h;

1: p-bromophenyl bromide With iodine; magnesium in diethyl ether 1 h; Heating; 2: Methyl ecgonidine in diethyl ether; dichloromethane T=-40°C; Grignard reaction; 3 h; 3: With trifluoroacetic acid in diethyl ether; dichloromethane T=-70 - -10°C;

1: diethyl ether 2: NaBr; NCS; HOAc View Scheme

Addition;