2,3-二氢-3,3-二甲基苯并呋喃-2-酮合成路线 （共 12 条）
反应条件
1: 2,3-dihydro-2-benzofuranone With sodium hydride in tetrahydrofuran; DMF (N,N-dimethyl-formamide) T=0°C; 2: methyl iodide in tetrahydrofuran; DMF (N,N-dimethyl-formamide) T=20°C; 1 h;
参考文献
Agouron Pharmaceuticals, Inc.
Patent: US2005/176701 A1, 2005 ;
Location in patent: Page/Page column 43 ;
US 20050176701 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide
参考文献
Hillery, Paul S.; Cohen, Louis A.
Journal of Organic Chemistry, 1983 , vol. 48, # 20 p. 3465 - 3471
反应条件
[bis(acetoxy)iodo]benzene; potassium acetate; palladium diacetate; N-acetyl-glycine in tert-butyl alcohol T=100°C; 12 h; Sealed tube; Reagent/catalystTemperature;
参考文献
Cheng, Xiu-Fen; Li, Yan; Su, Yi-Ming; Yin, Feng; Wang, Jian-Yong; Sheng, Jie; Vora, Harit U.; Wang, Xi-Sheng; Yu, Jin-Quan
Journal of the American Chemical Society, 2013 , vol. 135, # 4 p. 1236 - 1239
反应条件
copper dichloride in ethylene glycol T=150°C; 1 h;
参考文献
Miyake, Hideyoshi; Nishimura, Akinori; Yago, Misato; Sasaki, Mitsuru
Chemistry Letters, 2007 , vol. 36, # 2 p. 332 - 333
反应条件
tri-ruthenium(0)dodecacarbonyl; 2,4,5-trimethyl-1-phenyl-1H-imidazole in 1,3,5-trimethyl-benzene T=135°C; 24 h; Inert atmosphere;
参考文献
Konishi, Hideyuki; Muto, Takashi; Manabe, Kei; Ueda, Tsuyoshi
Organic Letters, 2012 , vol. 14, # 18 p. 4722 - 4725,4
反应条件
[bis(acetoxy)iodo]benzene; silver(I) acetate; caesium acetate; sodium acetate; palladium diacetate in chlorobenzene; tert-butyl alcohol T=100°C; 12 h; Inert atmosphere; Overall yield = 40 percent;
参考文献
Yang, Mingyu; Jiang, Xingyu; Shi, Wen-Juan; Zhu, Qi-Lei; Shi, Zhang-Jie
Organic Letters, 2013 , vol. 15, # 3 p. 690 - 693
反应条件
1.1: potassium tert-butylate / tetrahydrofuran / 2 h / 20 °C 1.2: -78 - 30 °C 2.1: sodium hydrogencarbonate / neat (no solvent) / 20 °C 3.1: tri-ruthenium(0)dodecacarbonyl; 2,4,5-trimethyl-1-phenyl-1H-imidazole / 1,3,5-trimethyl-benzene / 24 h / 135 °C / |Inert atmosphere View Scheme
参考文献
Konishi, Hideyuki; Muto, Takashi; Manabe, Kei; Ueda, Tsuyoshi
Organic Letters, 2012 , vol. 14, # 18 p. 4722 - 4725,4
反应条件
1: sodium hydrogencarbonate / neat (no solvent) / 20 °C 2: tri-ruthenium(0)dodecacarbonyl; 2,4,5-trimethyl-1-phenyl-1H-imidazole / 1,3,5-trimethyl-benzene / 24 h / 135 °C / |Inert atmosphere View Scheme
参考文献
Konishi, Hideyuki; Muto, Takashi; Manabe, Kei; Ueda, Tsuyoshi
Organic Letters, 2012 , vol. 14, # 18 p. 4722 - 4725,4
参考文献
Nasarow; Kusnetzowa
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1942 , p. 392
Chem.Abstr., 1945 , p. 1620
反应条件
1: aqueous phosphoric acid 2: ozone View Scheme
参考文献
Nasarow; Kusnetzowa
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1942 , p. 392
Chem.Abstr., 1945 , p. 1620
