1,3,4-三甲基尿嘧啶合成路线 （共 42 条）
参考文献
Behrend; Thurm
Justus Liebigs Annalen der Chemie, 1902 , vol. 323, p. 165
反应条件
T=300 - 350°C; Unter Druck;
参考文献
Chi; Ling
Scientia Sinica (English Edition), 1955 , vol. 4, p. 119,125
反应条件
selenium(IV) oxide in acetic acid
T=100°C; 4 h;
参考文献
GLENMARK PHARMACEUTICALS S.A.; KUMAR, Sukkeerthi; THOMAS, Abraham; WAGHMARE, Nayan, Taterao; KHAIRATKAR-JOSHI, Neelima; MUKHOPADHYAY, Indranil
Patent: WO2011/132017 A1, 2011 ;
WO 2011/132017 A1
反应条件
in acetone
Irradiation;
参考文献
Szilagyi, Geza; Wamhoff, Heinrich
Angewandte Chemie, 1983 , vol. 95, # 2 p. 156 - 157
反应条件
1: zinc(II) chloride / chlorobenzene / 3 h / Reflux
2: water; bromine / tetrachloromethane; dichloromethane / 0.17 h / 50 °C
3: ethanol / 1 h / Reflux
4: toluene-4-sulfonic acid / 1,2-dichloro-ethane / 0.08 h / Reflux
View Scheme
参考文献
Snyder, David S.; Tradtrantip, Lukmanee; Yao, Chenjuan; Kurth, Mark J.; Verkman
Journal of Medicinal Chemistry, 2011 , vol. 54, # 15 p. 5468 - 5477
反应条件
1: P2O5; HNO3
2: SnCl2; aqueous HCl
4: benzene
View Scheme
参考文献
Senda; Suzui
Chemical and Pharmaceutical Bulletin, 1958 , vol. 6, p. 476,478
反应条件
1: 79 percent / HNO3, H2SO4 / 0 - 5 °C
2: 66 percent / dimethylformamide / 2 h / Ambient temperature
3: 36 percent / H2 / 10percent Pd/C / methanol / 2 h / 760 Torr / Ambient temperature
View Scheme
参考文献
Baraldi, Pier Giovanni; Romagnoli, Romeo; Saponaro, Giulia; Aghazadeh Tabrizi, Mojgan; Baraldi, Stefania; Pedretti, Pamela; Fusi, Camilla; Nassini, Romina; Materazzi, Serena; Geppetti, Pierangelo; Preti, Delia
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 5 p. 1690 - 1698
反应条件
lithium diisopropyl amide
1.) THF, -40 deg C; Yield given. Multistep reaction;
参考文献
Satyanarayana; Reddy; Ila; Junjappa
Tetrahedron Letters, 1992 , vol. 33, # 41 p. 6173 - 6176
反应条件
1.) THF, -78 deg C, LHMDS, 1 h, 2.) THF, -50 deg C, 6 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Botta, Maurizio; Saladino, Raffaele; Delle Monache, Giuliano; Gentile, Gabriella; Nicoletti, Rosario
Heterocycles, 1996 , vol. 43, # 8 p. 1687 - 1697
反应条件
1: P2O5; HNO3
2: SnCl2; aqueous HCl
View Scheme
参考文献
Senda; Suzui
Chemical and Pharmaceutical Bulletin, 1958 , vol. 6, p. 476,478
