1,3,4-三甲基尿嘧啶合成路线 （共 42 条）
反应条件
tetra(n-butyl)ammonium hydrogensulfate; ethane-1,2-dithiol in N,N-dimethyl-formamide
T=30 - 40°C; 30 h;
参考文献
Kumar, Subodh; Chimni, Swapandeep Singh
Journal of Chemical Research, Miniprint, 1992 , # 1 p. 343 - 359
反应条件
tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; ethane-1,2-dithiol in N,N-dimethyl-formamide
T=30 - 40°C;
参考文献
Kumar, Subodh; Chimni, Swapandeep Singh
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1994 , vol. 33, # 2 p. 179 - 181
参考文献
Case; Hill
Journal of the American Chemical Society, 1930 , vol. 52, p. 1536,1540
反应条件
1.1: 80 percent / ammonium persulfate / ethanol / 12 h / Heating
2.1: 88 percent / magnesium monoperoxyphthalate / ethanol; H2O / 1 h / 50 °C
3.1: sodium hydride / tetrahydrofuran / 3 h / Heating
3.2: 34 percent / tetrahydrofuran / 12 h / 20 °C
4.1: 92 percent / Raney nickel / H2O; ethanol / 0.5 h / 20 °C
View Scheme
参考文献
Norris, Peter; Shechter, Harold
Journal of Organic Chemistry, 1999 , vol. 64, # 20 p. 7290 - 7298
反应条件
1.1: 80 percent / m-CPBA / CH2Cl2 / 3 h / 20 °C
2.1: NaH / tetrahydrofuran / 3 h / Heating
2.2: 67 percent / tetrahydrofuran / 1 h / 20 °C
3.1: 42 percent / Raney nickel / ethanol; H2O / 1 h / 20 °C
View Scheme
参考文献
Norris, Peter; Shechter, Harold
Journal of Organic Chemistry, 1999 , vol. 64, # 20 p. 7290 - 7298
反应条件
1: sodium ethanolate / ethanol / 72 h / 20 °C
2: hydrogen bromide / 1 h / Reflux
View Scheme
参考文献
Sajiki, Hironao; Iida, Yusuke; Ikawa, Kanoko; Sawama, Yoshinari; Monguchi, Yasunari; Kitade, Yukio; Maki, Yoshifumi; Inoue, Hideo; Hirota, Kosaku
Molecules, 2012 , vol. 17, # 6 p. 6519 - 6546
反应条件
sodium hydroxide
T=20°C; Methylation; hydrolysis; 1 h;
参考文献
Gambacorta, Augusto; Farah, Mohamed Elmi; Tofani, Daniela
Tetrahedron, 1999 , vol. 55, # 43 p. 12615 - 12628
反应条件
potassium carbonate in dimethyl sulfoxide
15 h;
参考文献
Kusmierek, Jaroslav; Kaeppi, Rainer; Neuvonen, Kari; Shugar, David; Loennberg, Harri
Acta Chemica Scandinavica, 1989 , vol. 43, # 2 p. 196 - 202
反应条件
1: aqueous-alcoholic KOH-solution
View Scheme
参考文献
Behrend; Thurm
Justus Liebigs Annalen der Chemie, 1902 , vol. 323, p. 165
参考文献
Lacey
Journal of the Chemical Society, 1954 , p. 854,859
