1,3,4-三甲基尿嘧啶合成路线 （共 42 条）
参考文献
Justus Liebigs Annalen der Chemie, , vol. 244, p. 15
参考文献
Justus Liebigs Annalen der Chemie, , vol. 244, p. 15
参考文献
Watanabe, K. A.; Su, T.-L.; Pankiewicz, K. W.; Harada, K.
Heterocycles, 1984 , vol. 21, # 1 p. 289 - 307
反应条件
1.) THF, -78 deg C, LHMDS, 1 h, 2.) THF, -78 deg C, 6 h; Yield given. Multistep reaction;
参考文献
Botta, Maurizio; Saladino, Raffaele; Delle Monache, Giuliano; Gentile, Gabriella; Nicoletti, Rosario
Heterocycles, 1996 , vol. 43, # 8 p. 1687 - 1697
参考文献
GLENMARK PHARMACEUTICALS, S.A.; KUMAR, Sukeerthi; THOMAS, Abraham; GAIKWAD, Siddeshwar, Shrimant; MARGAL, Sanjay; PHATANGARE, Shantaram, Kashinath; IRLAPATI, Nageswara, Rao; KHAIRATKAR-JOSHI, Neelima; MUKHOPADHYAY, Indranil
Patent: WO2010/125469 A1, 2010 ;
Location in patent: Page/Page column 35 ;
WO 2010/125469 A1
反应条件
1.) THF, -78 deg C, LHMDS, 1 h, 2.) THF, -50 deg C, 6 h; Yield given. Multistep reaction;
参考文献
Botta, Maurizio; Saladino, Raffaele; Delle Monache, Giuliano; Gentile, Gabriella; Nicoletti, Rosario
Heterocycles, 1996 , vol. 43, # 8 p. 1687 - 1697
反应条件
N-bromosuccinmide; 3BrH*C6H15N; potassium carbonate in dichloromethane T=0 - 20°C;
参考文献
Jyothi, Divya; Hariprasad
Synlett, 2009 , # 14 p. 2309 - 2311
反应条件
sodium hydroxide in water
T=25°C; 72 h;
参考文献
Snyder, David S.; Tradtrantip, Lukmanee; Yao, Chenjuan; Kurth, Mark J.; Verkman
Journal of Medicinal Chemistry, 2011 , vol. 54, # 15 p. 5468 - 5477
反应条件
nickel in ethanol; water
T=20°C; Reduction; 0.5 h;
参考文献
Norris, Peter; Shechter, Harold
Journal of Organic Chemistry, 1999 , vol. 64, # 20 p. 7290 - 7298
反应条件
4-(N,N-dimethlyamino)pyridine in pyridine
2 h; Ambient temperature;
参考文献
Egg, H.; Volgger, I.
Synthesis, 1982 , # 12 p. 1071 - 1073
