hydrogenchloride in dichloromethane; water T=15 - 20°C;

1.1: hydrogenchloride / dichloromethane; water / 15 - 20 °C 2.1: triethylamine / hexane / 3 h / -40 °C 3.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / 0 °C 3.2: 3 h / -78 °C 4.1: acetonitrile / 20 h / Reflux 4.2: 3 h / 20 °C / Cooling with ice View Scheme

1.1: hydrogenchloride / dichloromethane; water / 15 - 20 °C 2.1: triethylamine / hexane / 3 h / -40 °C 3.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / 0 °C 3.2: 3 h / -78 °C View Scheme