3-羟基甲基-4-甲氧基苯胺合成路线 （共 5 条）
反应条件
hydrogen; platinum(IV) oxide in methanol T=17 - 25°C; P=1520.1 Torr; 3 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/40526 A1, 2006 ;
Location in patent: Page/Page column 97 ;
WO 2006/040526 A1
反应条件
tin(ll) chloride in ethanol T=70°C; 1 h;
参考文献
Hangauer, David G.
Patent: US2008/4241 A1, 2008 ;
Location in patent: Page/Page column 76 ;
US 20080004241 A1
参考文献
Rhone-Poulenc Rorer S.A.
Patent: US5382590 A1, 1995 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=20°C; 7 h;
参考文献
Hirashima, Shintaro; Oka, Takahiro; Ikegashira, Kazutaka; Noji, Satoru; Yamanaka, Hiroshi; Hara, Yoshinori; Goto, Hiroyuki; Mizojiri, Ryo; Niwa, Yasushi; Noguchi, Toru; Ando, Izuru; Ikeda, Satoru; Hashimoto, Hiromasa
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 11 p. 3181 - 3186
反应条件
1: iron; NH4Cl / tetrahydrofuran; methanol; H2O / 3 h / 100 °C 2: LiAlH4 / tetrahydrofuran / 7 h / 20 °C View Scheme
参考文献
Hirashima, Shintaro; Oka, Takahiro; Ikegashira, Kazutaka; Noji, Satoru; Yamanaka, Hiroshi; Hara, Yoshinori; Goto, Hiroyuki; Mizojiri, Ryo; Niwa, Yasushi; Noguchi, Toru; Ando, Izuru; Ikeda, Satoru; Hashimoto, Hiromasa
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 11 p. 3181 - 3186
