2-脱氧-2,2-二氟-呋喃核糖基-3,5-二苯甲酰基-1-甲磺酸酯合成路线 （共 8 条）
反应条件
triethylamine in dichloromethane T=23°C; 2 h;
参考文献
Quintiliani, Maurizio; Persoons, Leentje; Solaroli, Nicola; Karlsson, Anna; Andrei, Graciela; Snoeck, Robert; Balzarini, Jan; McGuigan, Christopher
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 14 p. 4338 - 4345
反应条件
1: 100 percent / LiAl(OBu-t)3H / diethyl ether; tetrahydrofuran / 1 h / 10 - 30 °C 2: 100 percent / triethylamine / CH2Cl2 / 2 h / 23 °C View Scheme
参考文献
Synthesis, , # 6 p. 565 - 570
反应条件
trimethylsilyl trifluoromethanesulfonate in 1,2-dichloro-ethane T=83°C; 17 h; Product distribution / selectivity;
参考文献
Chou; Heath; Patterson; Poteet; Lakin; Hunt
Synthesis, 1992 , # 6 p. 565 - 570
反应条件
trimethylsilyl trifluoromethanesulfonate in 1,2-dichloro-ethane T=83°C; 17 h; Product distribution / selectivity;
参考文献
Chou; Heath; Patterson; Poteet; Lakin; Hunt
Synthesis, 1992 , # 6 p. 565 - 570
反应条件
trimethylsilyl trifluoromethanesulfonate 1) 1,1,2-trichloroethane, r.t., 30 min, 2) 113 deg C, 18 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Chou; Heath; Patterson; Poteet; Lakin; Hunt
Synthesis, 1992 , # 6 p. 565 - 570
反应条件
1: 4-acetylamino-1,2-dihydro-2-pyrimidone With chloro-trimethyl-silane; 1,1,1,3,3,3-hexamethyl-disilazane in 1,2-dichloro-ethane 3 h; Heating / reflux; 2: 3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-D-ribofuranosyl mesylate With trimethylsilyl trifluoromethanesulfonate in 1,2-dichloro-ethane T=20 - 75°C; 14 - 16 h; Heating / reflux; 3: With hydrogenchloride in water; 1,2-dichloro-ethane
参考文献
POLTURI, Ramesh, Babu; VENKATA, Subramanian, Hariharakrishnan; BETINI, Ramesh
Patent: WO2005/95430 A1, 2005 ;
Location in patent: Page/Page column 18-20 ;
反应条件
trimethylsilyl trifluoromethanesulfonate 1) 1,1,2-trichloroethane, r.t., 30 min, 2) 113 deg C, 18 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Chou; Heath; Patterson; Poteet; Lakin; Hunt
Synthesis, 1992 , # 6 p. 565 - 570
反应条件
1: 4-acetylamino-1,2-dihydro-2-pyrimidone With chloro-trimethyl-silane; 1,1,1,3,3,3-hexamethyl-disilazane in 1,2-dichloro-ethane 3 h; Heating / reflux; 2: 3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-D-ribofuranosyl mesylate With trimethylsilyl trifluoromethanesulfonate in 1,2-dichloro-ethane T=20 - 75°C; 14 - 16 h; Heating / reflux; 3: With hydrogenchloride in water; 1,2-dichloro-ethane
参考文献
POLTURI, Ramesh, Babu; VENKATA, Subramanian, Hariharakrishnan; BETINI, Ramesh
Patent: WO2005/95430 A1, 2005 ;
Location in patent: Page/Page column 18-20 ;
