反应条件
1: 1.) Mg, CCl4 / 1.) EtOH, Et2O, 3 h, 2.) EtOH, Et2O, THF, reflux, 16 h
2: 65 percent / H2SO4 / acetic acid; H2O / 3.5 h / Heating
3: 89 percent / SnCl2*2H2O, conc. aq. HCl / 0.12 h / 95 °C
4: 1.) NaNO2, 3percent aq. H2SO4, 2.) NaI / 1.) 0-5 deg C, 30 min, 2.) water, CH2Cl2, 5 deg C, 35 min
View Scheme
参考文献
Ulrich, Peter; Cerami, Anthony
Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 35 - 40
