4-羟基-6,7-二甲氧基喹啉合成路线 （共 16 条）
反应条件
potassium hydroxide in ethanol; water T=180°C; P=13446.2 - 14480.5 Torr; 0.833333 h; Microwave;
参考文献
PFIZER INC.
Patent: WO2005/121125 A1, 2005 ;
Location in patent: Page/Page column 41-42 ;
反应条件
1: With sodium methylate in ethylene glycol dimethyl ether T=20°C; 16.5 h; 2: With sodium ethanolate in ethylene glycol dimethyl ether T=20°C; 24 h;
参考文献
BAYER HEALTHCARE AG
Patent: WO2008/48375 A1, 2008 ;
Location in patent: Page/Page column 46-47 ;
反应条件
in 1,2-dichloro-benzene T=-20°C; Reflux;
参考文献
XI, Ning; WANG, Tingjin; ZENG, Shan; SUN, Mingming; WANG, Kunrui
Patent: WO2013/180949 A1, 2013 ;
Location in patent: Paragraph 0169 ;
反应条件
1: 3,4-dimethoxy-5-anilinoacetophenone With sodium t-butanolate in 1,4-dioxane 0.5 h; 2: orthoformic acid triethyl ester T=20°C; 2 h;
参考文献
WO2004/85425 A1, ;
Page 171-172 ;
WO 2004/085425 A1
反应条件
in hexane; ethyl acetate
参考文献
Xi, Ning
Patent: US2010/239576 A1, 2010 ;
US 20100239576 A1
反应条件
diphenylether; biphenyl
参考文献
Journal of the American Chemical Society, , vol. 68, p. 1264
反应条件
1: Erhitzen des Reaktionsprodukts in einem Gemisch von Diphenylaether und Biphenyl auf 250grad 2: aqueous NaOH 3: biphenyl; diphenyl ether View Scheme
参考文献
Journal of the American Chemical Society, , vol. 68, p. 1264
反应条件
in diphenylether T=300°C; 0.0833333 h; microwave irradiation;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 4 p. 1015 - 1018
反应条件
trichlorophosphate in toluene T=115°C; 1 h;
参考文献
XI, Ning; WANG, Tingjin; ZENG, Shan; SUN, Mingming; WANG, Kunrui
Patent: WO2013/180949 A1, 2013 ;
Location in patent: Paragraph 0170 ;
反应条件
ammonium hydroxide; trichlorophosphate in dichloromethane; acetonitrile
参考文献
Exelixis, Inc.
Patent: US2012/252840 A1, 2012 ;
US 20120252840 A1
