4,5,6,7-四氢-4-苯并噻吩合成路线 （共 38 条）
反应条件
1: 94 percent / ammonium acetate / acetic acid; benzene / 15 h / Heating
2: 86 percent / aq. ethanol / 0.58 h
3: 91 percent / conc. HCl / acetic acid / 120 h / Heating
View Scheme
参考文献
Stanetty; Frohlich; Sauter
Archiv der Pharmazie, 1984 , vol. 317, # 2 p. 168 - 176
反应条件
potassium cyanide in ethanol; water
T=80°C; 24 h; Sealed tube;
参考文献
ARES TRADING S.A.; QUATTROPANI, Anna; SWINNEN, Dominique
Patent: WO2013/178322 A1, 2013 ;
Location in patent: Page/Page column 60 ;
反应条件
(NH4)2CO3 in ethanol
T=110°C;
参考文献
Sarges; Schnur; Belletire; Peterson
Journal of Medicinal Chemistry, 1988 , vol. 31, # 1 p. 230 - 243
反应条件
ammonium acetate in acetic acid; benzene
15 h; Heating;
参考文献
Stanetty; Frohlich; Sauter
Archiv der Pharmazie, 1984 , vol. 317, # 2 p. 168 - 176
反应条件
1: 94 percent / ammonium acetate / acetic acid; benzene / 15 h / Heating
2: 86 percent / aq. ethanol / 0.58 h
View Scheme
参考文献
Stanetty; Frohlich; Sauter
Archiv der Pharmazie, 1984 , vol. 317, # 2 p. 168 - 176
参考文献
Alanine, Alexander; Buettelmann, Bernd; Heitz Neidhart, Marie-Paule; Pinard, Emmanuel; Wyler, Rene
Patent: US2003/144525 A1, 2003 ;
反应条件
1: hydrazine hydrate; potassium hydroxide; diethylene glycol / 215 °C
2: aluminium chloride
3: alkaline aqueous potassium hypobromite solution; dioxane
4: thionyl chloride / Behandeln des Reaktionsprodukts mit wss. Ammoniak
View Scheme
参考文献
Cagniant; Cagniant
Bulletin de la Societe Chimique de France, 1953 , p. 62,68, 713, 717
反应条件
in dichloromethane
2 h; -40 to 0 deg C;
参考文献
Reetz, Manfred T.; Westermann, Juergen; Kyung, Suk-Hun
Chemische Berichte, 1985 , vol. 118, # 3 p. 1050 - 1057
