1-(4-羟基苯基)-5-氧代-3-吡咯烷羧酸甲酯合成路线 （共 6 条）
反应条件
sulfuric acid in dichloromethane 14 h; Heating;
参考文献
Watanabe, S.; Ogawa, K.; Ohno, T.; Yano, S.; Yamada, H.; Shirasaka, T.
European Journal of Medicinal Chemistry, 1994 , vol. 29, # 9 p. 675 - 686
参考文献
AMGEN INC.
Patent: WO2006/60318 A2, 2006 ;
Location in patent: Page/Page column 148 ;
WO 2006/060318 A2
反应条件
1: 93.5 percent / Heating 2: 94.7 percent / conc. H2SO4 / CH2Cl2 / 14 h / Heating View Scheme
参考文献
Watanabe, S.; Ogawa, K.; Ohno, T.; Yano, S.; Yamada, H.; Shirasaka, T.
European Journal of Medicinal Chemistry, 1994 , vol. 29, # 9 p. 675 - 686
反应条件
1: 93.5 percent / Heating 2: 94.7 percent / conc. H2SO4 / CH2Cl2 / 14 h / Heating View Scheme
参考文献
Watanabe, S.; Ogawa, K.; Ohno, T.; Yano, S.; Yamada, H.; Shirasaka, T.
European Journal of Medicinal Chemistry, 1994 , vol. 29, # 9 p. 675 - 686
反应条件
1: 96 percent / K2CO3 / dimethylformamide / 80 °C
2: 94.5 percent / NaBH4, MeOH / tetrahydrofuran / Heating
View Scheme
参考文献
Watanabe, S.; Ogawa, K.; Ohno, T.; Yano, S.; Yamada, H.; Shirasaka, T.
European Journal of Medicinal Chemistry, 1994 , vol. 29, # 9 p. 675 - 686
反应条件
hydrogenchloride; potassium carbonate in N-methyl-acetamide
参考文献
Otsuka Pharmaceutical Company, Limited
Patent: US5145865 A1, 1992 ;
