5-氯-6-(1-环己烯-1-基)-苯-d4合成路线 （共 4 条）
反应条件
sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid in dichloromethane T=0 - 25°C;
参考文献
Sulake, Rohidas S.; Chen, Chinpiao; Lin, Huei-Ru; Lua, Ahai-Chang
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 19 p. 5719 - 5721
反应条件
1: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 25 °C 2: water; hydrogen bromide / chloroform / 0.5 h / 20 °C 3: pyridinium chlorochromate / dichloromethane / 13 h / 20 °C 4: sodium azide / dimethyl sulfoxide / 5 h / 25 °C View Scheme
参考文献
Sulake, Rohidas S.; Chen, Chinpiao; Lin, Huei-Ru; Lua, Ahai-Chang
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 19 p. 5719 - 5721
反应条件
1: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 25 °C 2: water; hydrogen bromide / chloroform / 0.5 h / 20 °C 3: pyridinium chlorochromate / dichloromethane / 13 h / 20 °C View Scheme
参考文献
Sulake, Rohidas S.; Chen, Chinpiao; Lin, Huei-Ru; Lua, Ahai-Chang
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 19 p. 5719 - 5721
反应条件
1.1: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 25 °C 2.1: water; hydrogen bromide / chloroform / 0.5 h / 20 °C 3.1: pyridinium chlorochromate / dichloromethane / 13 h / 20 °C 4.1: sodium azide / dimethyl sulfoxide / 5 h / 25 °C 5.1: triphenylphosphine / tetrahydrofuran / 12 h / 65 °C 5.2: 3 h / Reflux 6.1: hydrogen bromide; bromine / water / 70 °C 7.1: DBN / acetonitrile / 25 h / Reflux View Scheme
参考文献
Sulake, Rohidas S.; Chen, Chinpiao; Lin, Huei-Ru; Lua, Ahai-Chang
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 19 p. 5719 - 5721
