2-氯-3-氨基-4-甲基吡啶合成路线 （共 27 条）
反应条件
sodium hydroxide; bromine in water 1.) 5 deg C; 2.) 75 deg C, 90 min;
参考文献
Zhang; Stout; Keay; Scriven; Toomey; Goe
Tetrahedron, 1995 , vol. 51, # 48 p. 13177 - 13184
反应条件
hydrogenchloride; dihydrogen peroxide T=20°C; 0.5 h;
参考文献
Bakke; Riha
Journal of Heterocyclic Chemistry, 2001 , vol. 38, # 1 p. 99 - 104
反应条件
hydrogenchloride; tin(ll) chloride in diethyl ether 0.333333 h; Ambient temperature;
参考文献
Norman; Minick; Martin
Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 3 p. 771 - 779
反应条件
sodium hydroxide; acetic acid in hydrogenchloride; water
反应条件
1: 97 percent / H2 / 5 percent Pd/C / methanol / 5 h / 20 °C / 3750.3 Torr 2: 89 percent / conc. aq. HCl; 35 percent aq. H2O2 / 0.5 h / 20 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 38, # 1 p. 99 - 104
反应条件
1: NH3(g) / toluene / below 30 deg C 2: 93 percent / NaOH, Br2 / H2O / 1.) 5 deg C; 2.) 75 deg C, 90 min View Scheme
参考文献
Tetrahedron, , vol. 51, # 48 p. 13177 - 13184
反应条件
1: 90 percent / NaOH / methanol; H2O / 75 °C 2: SOCl2 / toluene / 1.) 70 deg C, 1 h; 2.) reflux, 4 h 3: NH3(g) / toluene / below 30 deg C 4: 93 percent / NaOH, Br2 / H2O / 1.) 5 deg C; 2.) 75 deg C, 90 min View Scheme
参考文献
Tetrahedron, , vol. 51, # 48 p. 13177 - 13184
反应条件
1: SOCl2 / toluene / 1.) 70 deg C, 1 h; 2.) reflux, 4 h 2: NH3(g) / toluene / below 30 deg C 3: 93 percent / NaOH, Br2 / H2O / 1.) 5 deg C; 2.) 75 deg C, 90 min View Scheme
参考文献
Tetrahedron, , vol. 51, # 48 p. 13177 - 13184
反应条件
1: 17 percent / PCl3, HCl(g) / dimethylformamide / 1.) 85 deg C; 2.) 90 deg C 2: 90 percent / NaOH / methanol; H2O / 75 °C 3: SOCl2 / toluene / 1.) 70 deg C, 1 h; 2.) reflux, 4 h 4: NH3(g) / toluene / below 30 deg C 5: 93 percent / NaOH, Br2 / H2O / 1.) 5 deg C; 2.) 75 deg C, 90 min View Scheme
参考文献
Tetrahedron, , vol. 51, # 48 p. 13177 - 13184
反应条件
1.1: trichlorophosphate / 2 h / 35 °C / Reflux 2.1: sulfuric acid / 4 h / 50 - 105 °C 2.2: 1.5 h / 60 - 65 °C 2.3: pH 7 / Cooling with ice 3.1: sodium hypochlorite; sodium hydroxide / methanol; water / 4 h / 10 - 60 °C View Scheme
参考文献
Research on Chemical Intermediates, , vol. 37, # 6 p. 599 - 604
