1: LDA / hexamethylphosphoric acid triamide; tetrahydrofuran / 0.25 h / -78 °C 2: 77 percent / LiAlH4 / diethyl ether / 6 h / Ambient temperature View Scheme

lithium diisopropyl amide in tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide T=-78°C; 0.25 h;

1: LDA / hexamethylphosphoric acid triamide; tetrahydrofuran / 0.25 h / -78 °C 2: 77 percent / LiAlH4 / diethyl ether / 6 h / Ambient temperature 3: 95 percent / imidazole / dimethylformamide / 12 h / Ambient temperature View Scheme